The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro

Foo, Lai Yeap; Lu, Ying; Howell, Amy B.; Vorsa, Nicholi

doi:10.1016/s0031-9422(99)00573-7

Cited by 399 publications

(377 citation statements)

References 19 publications

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“…]; both species showed good activity. Simeray et al (1982) and Foo et al (2000) also reported antimicrobial activity of tannins present in different species. The anticarcinogenic and antimutagenic potentials of tannins may be related to their antioxidative properties important in preventing cellular oxidative damage, including lipid peroxidation (Haslam, 1998).…”

Section: Introductionmentioning

confidence: 93%

Antioxidant and antifungal activities of extracts and condensed tannins from Stryphnodendron obovatum Benth.

Sanches

Lopes²,

Nakamura³

et al. 2005

Rev. Bras. Cienc. Farm.

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Section: Introductionmentioning

confidence: 93%

Antioxidant and antifungal activities of extracts and condensed tannins from Stryphnodendron obovatum Benth.

Sanches

Lopes²,

Nakamura³

et al. 2005

Rev. Bras. Cienc. Farm.

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“…It has been concluded that vitamin C supplementation may not decrease URTI morbidity, 14 but phytophenols may promote health and diminish URTI. 4,5,[15][16][17][18][19] There are, however, other potential explanations such as supplementation by energy ingredients due to nectar, 12 and among young skiers high URTI morbidity was partly explained by great gap between high training load and low nutritional energy intake. Moreover, the post-exhaustion related open window of immunity may be modulated by phytophenols, while phytophenols like tannins decrease the oxidative damage including lipid peroxidation, 20,21 which might diminish post-exhaustive exercise related low immunity phase.…”

Section: Population Immunitymentioning

confidence: 99%

Berry-Vegetable Nectar May Help to Diminish Hospital Visits and Service Reliefs in Conscripts during the High Risk Period of Upper Respiratory Tract Infections

Tompuri¹,

Hänninen²

2015

Adv Food Technol Nutr Sci Open J

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Citation ResearchPage 67 ABSTRACTPhytophenols can counteract Upper Respiratory Tract Infections (URTI) by effecting on the microbes or by promoting immunity. At population level URTI has high economic significance. The aim of the study was to clarify if hospital visits or hospitalization or service reliefs from military service in conscripts could be diminished by phytophenol rich berry-vegetable nectar supplementation during high URTI-risk period. The 6.5 week intervention was carried out during highest URTI-risk at winter. The intervention subjects were predominantly healthy male conscripts (n=188) in a four military companies. Controls were either from same four companies (n=359) or from eleven other companies (n=1597). All conscripts lived in a same garrison within similar environment and had similar exercise program and had similar diet ad libitum. Intervention subjects received three portions of berry-vegetable nectar in a day. Weekly visits at the hospital, service reliefs and days in the hospital per company were recorded. Effect by intervention was analyzed between intervention and control companies by repeated measures analysis of variance. Intervention effect by berry-vegetable nectar was seen as a lower amount of visits at the hospital clinic (p=0.002), and as a lower amount of reliefs from outdoor service (p=0.049), while significant effect on hospitalization or on releases from indoor and outdoor reliefs was not observed. We conclude that nutritional supplementation byphytophenol rich berry-vegetable nectar may diminish hospital visits and reliefs from outdoor service in conscripts during high URTI-risk period.

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“…Preventing adhesion facilitates urinary flushing of the bacteria, and thereby preventing bacterial colonisation of the urinary tract (Foo et al, 2000).…”

Section: Relevance Of the Claimed Effect To Human Healthmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to Pacran® and defence against bacterial pathogens in the lower urinary tract pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Products¹

2014

EFS2

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Following an application from Naturex SA, submitted pursuant to Article 13(5) of Regulation (EC) via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Pacran® and defence against bacterial pathogens in the lower urinary tract. The food that is the subject of the claim is Pacran®. The Panel considers that the food, Pacran®, which is the subject of the claim is sufficiently characterised in relation to the claimed effect. The Panel considers that defence against bacterial pathogens in the lower urinary tract is a beneficial physiological effect. One human study from which conclusions could be drawn for the scientific substantiation of the claim showed no effect of Pacran® on defence against bacterial pathogens in the lower urinary tract. The Panel concludes that a cause and effect relationship has not been established between the consumption of Pacran® and defence against bacterial pathogens in the lower urinary tract. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The application includes a request for the protection of proprietary data.The food that is the subject of the health claim is Pacran®, which contains cranberry powder obtained from the blend of whole North American cranberries (Vaccinium macrocarpon, syn. V. macrocarpon Aiton or V. macrocarpon L). The applicant claims that proanthocyanidins (PACs) are the main food constituent in the Pacran® which are responsible for the claimed effect. The Panel considers that the food, Pacran®, which is the subject of the health claim is sufficiently characterised in relation to the claimed effect.The claimed effect proposed by the applicant is "helps to inhibit the adhesion of P-fimbriated Escherichia coli to the urinary tract cells". The target population proposed by the applicant is "sexually active women with a history of UTIs". The Panel considers that the claimed effect refers to defence against bacterial pathogens in the lower urinary tract in healthy women without signs or symptoms of a urinary tract infection (UTI) and does not include the treatment of UTI. The Panel considers that defence against bacterial pathogens in the lower urinary tract is a beneficial physiological effect.The applicant identified four studies as pertinent to the claim: two human intervention studies and two ex vivo studies. The Panel considers that no conclusions can be drawn from one of the human studies for the scientific substantiation of the claim and that the second human study had design limitations but did not show an effect of Pacran® on defence against bacterial pathogens in the lower urinary tract.In addition, the applicant provided two studies on the ex vivo anti-adherence properties of urine from subjects consuming Pacran® on uropathogenic E. coli strains as being pertinent to the claim. The Panel considers that these studies do not provide evidence that an...

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The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro

Cited by 399 publications

References 19 publications

Antioxidant and antifungal activities of extracts and condensed tannins from Stryphnodendron obovatum Benth.

Antioxidant and antifungal activities of extracts and condensed tannins from Stryphnodendron obovatum Benth.

Berry-Vegetable Nectar May Help to Diminish Hospital Visits and Service Reliefs in Conscripts during the High Risk Period of Upper Respiratory Tract Infections

Scientific Opinion on the substantiation of a health claim related to Pacran® and defence against bacterial pathogens in the lower urinary tract pursuant to Article 13(5) of Regulation (EC) No 1924/2006

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