The structure of desmosomes and their role in malignant disease

Garrod, David R.; Parrish, Elaine P.; Marston, J

doi:10.1042/bst0150802

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…By contrast, Dp I and II, the antigens recognised by 11-5F, are ubiquitous components of desmosomes (except that DpII is not expressed in cardiac muscle) (Suhrbier and Garrod, 1986;Angst et al, 1990). Staining with 11-5F, an extremely reliable indicator of desmosomes in various tumours Collins et al, 1990) , 1978;Garrod et al, 1987;Collins et al, 1990;Garrod, 1995). Such observations raise the possibility that desmo- Garrod, 1995) and that desmosomes may have a tumour suppressor function.…”

Section: Dicsasiomentioning

confidence: 99%

Immunohistochemical staining of desmosomal components in oral squamous cell carcinomas and its association with tumour behaviour

Hiraki

Shinohara²,

Ikebe³

et al. 1996

Br J Cancer

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Sumary Desmosomes are intercellular junctions that have been shown to be down-regulated in certain types of carcinomas and that may play a role in suppression of invasion and metastasis. We have shown previously that immunohistochemical staining for the major desmosomal glycoprotein, desmoglein (Dsg), is reduced in some cases of squamous cell carcinoma (SCC) of the head and neck, and that reduced staining correlates with lymph node involvement. Desmosomes are multicomponent organelles. We therefore sought to determine whether another major desmosomal mokcule, desmoplakin (Dp), showed similar reduced expression to that shown by desmoglein. We have stained 65 specimens of primary SCC of the oral cavity (37 non-metastatic and 28 metatastic) with monoclonal antibodies to both desmoglein and desmoplak-in. We show that reduction of Dp staining correlates with loss of differentiation of the primary tumour, degree of invasion and presence of lymph node metastases. Similar correlations were found with Dsg staining. There was also correlation between reduction in Dp staining and reduction in Dsg staining. It is concluded that down-regulation of desmosomal expression occurs in some cases of SCC of the oral cavity and is associated with invasion and metastasis. Desmosomes may have an invasion and metastasis suppressor function.

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Section: Dicsasiomentioning

confidence: 99%