The structure of emotional and cognitive anxiety symptoms

Kristensen, Ann Suhl; Mortensen, Erik Lykke; Mors, Ole

doi:10.1016/j.janxdis.2009.01.009

Cited by 9 publications

(8 citation statements)

References 61 publications

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“…But these individuals also demonstrated increased connectivity with the central “cognitive” precuneus (Figure 3; [26]). As the seed region (p4; Figure 1) is involved in limbic processing [26] and the central precuneus is involved in higher-order cognitive function [68], [69], [70], this connection suggests that Neuroticism involves increased integration of social and emotional information [7], [35], [71] and may relate to increased sensitivity to social-emotional cognitive conflicts [72], [73]. Yet this same seed (p4; Figure 1) is also connected to the dorsomedial prefrontal cortex (Figure 3), a region involved in self-evaluation [41] and social interaction [74].…”

Section: Discussionmentioning

confidence: 99%

Personality Is Reflected in the Brain's Intrinsic Functional Architecture

et al. 2011

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Personality describes persistent human behavioral responses to broad classes of environmental stimuli. Investigating how personality traits are reflected in the brain's functional architecture is challenging, in part due to the difficulty of designing appropriate task probes. Resting-state functional connectivity (RSFC) can detect intrinsic activation patterns without relying on any specific task. Here we use RSFC to investigate the neural correlates of the five-factor personality domains. Based on seed regions placed within two cognitive and affective ‘hubs’ in the brain—the anterior cingulate and precuneus—each domain of personality predicted RSFC with a unique pattern of brain regions. These patterns corresponded with functional subdivisions responsible for cognitive and affective processing such as motivation, empathy and future-oriented thinking. Neuroticism and Extraversion, the two most widely studied of the five constructs, predicted connectivity between seed regions and the dorsomedial prefrontal cortex and lateral paralimbic regions, respectively. These areas are associated with emotional regulation, self-evaluation and reward, consistent with the trait qualities. Personality traits were mostly associated with functional connections that were inconsistently present across participants. This suggests that although a fundamental, core functional architecture is preserved across individuals, variable connections outside of that core encompass the inter-individual differences in personality that motivate diverse responses.

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Section: Discussionmentioning

confidence: 99%

Personality Is Reflected in the Brain's Intrinsic Functional Architecture

et al. 2011

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“…Differences in conceptualization and assessment may account for this counterintuitive temporal The association. These cognitions are often observed in panic disorder, but have been linked with social phobia as well (99). This methodological issue may also explain the surprisingly higher rate of paranoid symptoms (15.7%) compared with social phobia (9.4%).…”

Section: Discussionmentioning

confidence: 99%

The association between social phobia, social anxiety cognitions and paranoid symptoms

Schutters

Dominguez

Knappe³

et al. 2011

Acta Psychiatr Scand

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“…1). The patients were diagnosed with PD or PD with agoraphobia and have been described before (Wang et al, 2006;Kristensen et al, 2009;Koefoed et al, 2010;Erhardt et al, 2011;Gregersen et al, 2012). The SNPs were analysed in three PD cohorts: 36 cases and 162 control individuals from the isolated population of the Faroe Islands, 243 cases and 649 control individuals from Denmark and 232 cases and 222 control individuals from Germany.…”

Section: Methodsmentioning

confidence: 99%

Are TMEM genes potential candidate genes for panic disorder?

Gregersen

Buttenschøn²,

Hedemand³

et al. 2014

Psychiatric Genetics

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We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

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The structure of emotional and cognitive anxiety symptoms

Cited by 9 publications

References 61 publications

Personality Is Reflected in the Brain's Intrinsic Functional Architecture

Personality Is Reflected in the Brain's Intrinsic Functional Architecture

The association between social phobia, social anxiety cognitions and paranoid symptoms

Are TMEM genes potential candidate genes for panic disorder?

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