Recent research has provided evidence that musical interaction can promote empathy. Yet little is known about the underlying intrapersonal and social psychological processes that are involved when this occurs. For example, which types of music increase empathy and which types decrease it; what role, if any, does empathy play in determining individual differences in musical preference, perception, and performance; or, how do these psychological underpinnings help explain the musical experiences of people with autism spectrum conditions (ASC). To address these questions we employ the Empathizing-Systemizing (E-S) theory as a fruitful framework in which to understand these music-related phenomena. Specifically, we explore how individual differences in musical preference, perception, and performance can be explained by E-S theory. We provide examples from open-ended descriptions of strong musical experiences to demonstrate the ways in which empathy and music inter-relate. Importantly, we discuss the implications for the study of autism, and for how music therapists and clinicians can use music as a tool in their work with individuals diagnosed with ASC.Submitted 2014 April 29; accepted 2014 June 29. KEYWORDS: empathy, autism, musical preference, perception, performance EMPATHY is a fundamental feature of human interaction. It requires both cognitive (Dennett, 1989;Baron-Cohen, 1995) and affective (Davis, 1994) components that enable people to recognize the emotional and mental states of others, and to respond to these with appropriate emotions (Harris, Johnson, Hutton, Andrews, & Cooke, 1989;Baron-Cohen & Wheelwright, 2004). Empathy allows for the perception of another's thoughts and feelings, and allows one to predict how they will behave (Whiten, 1991). Music listening and performance, which is a universal feature of human behavior (Blacking, 1995), also requires components of cognitive and affective processing. We listen and are exposed to music for hours each day (Motion Picture Association of America, Inc, 2007;Rentfrow, 2012), during which time we perceive the emotional and psychological content in music; interpret the thoughts, feelings, and proficiency of the musicians from auditory and visual cues (Thompson, Russo, & Quinto, 2008;Tsay, 2013); respond emotively to the music and the musician (Juslin, & Västfjäll, 2008;Zentner, Grandjean, & Scherer, 2008), and can predict the direction of a melodic phrase or narrative. Empathy is thus connected with the perception, interpretation, and emotional reactions to music.However, only recently have researchers in the field of music, personality, and social psychology begun to focus on how music and empathy are linked. For example, Wöllner (2012) showed that people with higher levels of empathy are able to perceive and identify a musician's intentions with greater accuracy than those with lower levels, and Egermann and McAdams (2013) demonstrated that perceived and induced emotion from music is moderated by empathy. Further, not only does empathy influenc...