Abstract. We give a complete study of the Clifford-Weyl algebra C(n, 2k) from BoseFermi statistics, including Hochschild cohomology (with coefficients in itself). We show that C(n, 2k) is rigid when n is even or when k = 1. We find all non-trivial deformations of C(2n + 1, 2) and study their representations.