The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine
Koen H. G. Verschueren,
Eleanor J. Dodson,
Anthony J. Wilkinson
Abstract:In Escherichia coli and Salmonella typhimurium, cysteine biosynthesis requires the products of 20 or more cys genes co-ordinately regulated by CysB. Under conditions of sulphur limitation and in the presence of the inducer, N-acetylserine, CysB binds to cys promoters and activates the transcription of the downstream coding sequences. CysB is a homotetramer, comprising an N-terminal DNA binding domain (DBD) and a C-terminal effector binding domain (EBD). The crystal structure of a dimeric EBD fragment of CysB f… Show more
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