The structure of the sesquiterpene lactone repin

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

“…Acroptilon repens Evstratova et al, 1966;Rybalko et al (1975), Gonzalez et al (1977a), Rustaiyan et al (1981b), , Mallabaev et al (1982), Rustaiyan and Nazarians (1984), Nowak et al (1986a), Stevens et al (1990), Robles et al (1997) Centaurea adjarica Nowak et al (1989a Geppert et al (1983), Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a et al, , Gonzalez et al (1977a, Rustaiyan et al (1981b), Mallabaev et al, 1982, Rustaiyan andNazarians (1984) Centaurea adjarica Nowak et al (1986dNowak et al ( , 1989aNowak et al ( , 1996 et al (1983), Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a,b) Centaurea hyrcanica Evstratova et al, 1972, Rybalko et al (1975, Gonzalez et al (1977a) Centaurea hyssopifolia Gonzalez et al, 1974b, 1977a, Nowak et al (1986a et al (1977a, 1978b), Nowak et al (1986a et al (1989a, 1996), Nowak (1992) Centaurea solstitialis Merrill and Stevens (1985), Jakupovic et al…”

Sesquiterpenoid alkaloid fromAcroptilon repens

“…Acroptilon repens L., refereed to as Centaurea repens or Centaurea picris in some literature [1], is a fast growing perennial weed of the family Asteraceae. The chemical investigation on this plant has resulted in the isolation of a number of sesquiterpenoids, some of which showed high cytotoxicity with Hela cells or toxicity toward chick embryo sensory neurons [2][3][4][5][6][7].…”

Guaianolides from the Aerial Parts of Centaurea Hololeuca

“…The major guaianolide, repin (1), isolated for the first time from Acroptilon repens [11], has been shown to exhibit a variety of biological activities. The ingestion of A.…”

“…From repin (1), we synthesized the mono-chloro-derivatives solstitiolide (8) and chlorohyssopifolin C ( 9) and the di-chloroderivative chlorohyssopifolin A (10). Similarly chlorojanerin (11) was prepared from janerin (3).…”

“…These four compounds (8)(9)(10)(11), already known as natural products, were previously isolated from Centaurea solstitialis [31], C. repens [32], C. hyssopifolia [33], and C. janeri [24], respectively, and shown to possess biological properties. In fact, chlorojanerin (11) was identified as the main component responsible for the anti-ulcerogenic activity of the fresh spiny flowers extract of C. solstitialis L. ssp. solstitialis [34].…”