The structure of the thyroid organ in man

Williamson, Geo. Scott; Pearse, Innes H.

doi:10.1002/path.1700260405

Cited by 29 publications

(5 citation statements)

References 4 publications

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“…Together they described a system of tubules in the secretory epithelium of the gland, which they described as “a new structure distributed through the parenchyma of certain secreting epithelia ... [consisting] of an extensive system of minute tubules linked together in the form of a network, which is stretched beneath the free surface of the epithelia.”4 They subsequently described two functions of the gland: (a) production of a secretion, which they called “lymphogenic” and which contained no thyroxine, and (b) accumulation of colloid, which did contain thyroxine 56789. The occurrence of a lymphogenic secretion led them to review about 4000 cases of goitre, looking for a form of pathology that would correspond to oversecretion.…”

Section: The Pioneer Health Centrementioning

confidence: 99%

When I use a word . . . Medical blue plaques—the Peckham Experiment

Aronson

2024

BMJ

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The Pioneer Health Centre in Peckham, also known as the Peckham Centre, running what became known at the Peckham Experiment, was founded in 1926 by two doctors, Innes Pearse (1889–1978) and her colleague George Scott Williamson (1884–1953). It closed down in 1929 and reopened in 1935 in new purpose-built premises. Families paid a shilling a week for membership, which gave them free medical consultations of various sorts and access to a wide variety of recreations, but no medical treatment. The purpose was to observe how their health progressed and to discover what factors were involved in good health and wellbeing. After closing down again during World War II the centre reopened, but was forced to close again in 1950, this time for good, because of lack of funds, due to a complex range of factors. In a 1938 publication, the founders stressed that health and wellbeing were not synonymous; health, they wrote, operates with a cumulative deposit account and wellbeing on a diminishing current account. Two blue plaques commemorate the Pioneer Health Centre: an English Heritage blue plaque at 142 Queen’s Road, Peckham, London SE15, the site of the centre’s original building, and a plaque put up by the London Borough of Southwark at the site of the second building, now converted to a block of flats, and situated round the corner from the Queen’s Road premises, in Frobisher Place, St Mary’s Road, Peckham.

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Section: The Pioneer Health Centrementioning

confidence: 99%

When I use a word . . . Medical blue plaques—the Peckham Experiment

Aronson

2024

BMJ

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“…[1933][1934][1935]) et l'impossibilité de les retrouver dans le sang (Trevorrow [1939], Lerman [1940], Harrington [1944], Gross et Pitt-Rivers [1952]) perm ettent d'abord de considérer comme invraisem blable l'hypothèse selon laquelle le «m aterial colloïdal», dans lequel sont contenues les thyroglobulines, pourrait être versé dans les sinusoïdes au moyen d'un processus de filtration intercellulaire ( Uhlenhuth [1928]; Williams [1937][1938][1939][1940][1941][1942][1943][1944], Williamson et Pearse [1923-1927, etc. ), ou transcellulaire (Aron [1930(Aron [ -1931 [1946], la colloïde directe m ent extraite de la cavité folliculaire contient un système protéo lytique, qui est actif quand il est à même d'opérer dans des con ditions physiologiques.…”

Section: Considérationsunclassified

RECHERCHES SUR LE MÉCANISME DE SÉCRÉTION DE LA CELLULE THYROÏDIENNE, SUIVI AVEC LE I<sup>131</sup>

Miani¹

1956

Cells Tissues Organs

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“…Pathology suggests that the main features of secondary Graves' disease are : (1) A preliminary exacerbative thyrotoxicosis ; ( 2 ) A chronic, or continuous thyrotoxicosis; (3) The supervention, a t a later date, o exophthalmos to complete the syndrome. This is the inverse sequence to that of primary Graves' disease.…”

Section: Disorders Of Secretionmentioning

confidence: 99%

The applied anatomy and physiology of the thyroid apparatus

Williamson¹

1926

Journal of British Surgery

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INTRODUCTORY.IN presenting some new aspects of the anatomy and physiology of the thyroid apparatus. I wish to indicatc how these new facts can assist the clinician in arriving a t a more rational understanding of the relation, one to another, of the groups of diseases of the thyroid gland, in the hope that a more critical study of the symptoms presented by these diseases will ultimately lead to an understanding of the part played by the thyroid gland in the metabolic turnover. The subject, I think, is one that will repay close study by team workers. There is a tendency to discredit the anatomist and to exclude him from these teams. It is forgotten, perhaps, that the design and architecture of any engine is very completely controlled by the nature of the fuel and the manner in which that fuel is to be transformed into work. An engineer presented with a piston or a cylinder, or other pa-k-even a damaged (pathological) member-f the engine, can very accurately deduce the nature of the fuel and the method of burning it. We are only beginning again to study anatomy from such a point of view, and already this is yielding results, as may be seen in the work of Aschoff and his pupils.The germ of this vital attitude to anatomy is manifest everywhere in the works of John Hunter. It has awaited the quickening that lies in the new ground of modern physiology, as exemplified in the remarkable books of the late Sir William Bay1iss.f It has but a remote relation to the study of the effect of death on cells and tissues, and none t o the classificatory treatment of pathology, as Bland-Sutton has pointed out in his treatise on tumours.1 I propose, therefore, to look at the anatomy of the thyroid apparatus from this 'vital' point of view.The subject matter of this paper represents the joint work of Dr. Innes Pearse and the author.

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The structure of the thyroid organ in man

Cited by 29 publications

References 4 publications

When I use a word . . . Medical blue plaques—the Peckham Experiment

When I use a word . . . Medical blue plaques—the Peckham Experiment

RECHERCHES SUR LE MÉCANISME DE SÉCRÉTION DE LA CELLULE THYROÏDIENNE, SUIVI AVEC LE I<sup>131</sup>

The applied anatomy and physiology of the thyroid apparatus

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