The structure of triterpenic glycosides from the flowers of Calendula officinalis L.

Kasprzyk, Zofia; Wojciechowski, Zdzisław A.

doi:10.1016/0031-9422(67)85009-x

Cited by 54 publications

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“…The extracts of Calendula officinalis contain phenolic acids, sterols, carotenoids, sugars, flavonoids, triterpenic alcohols, b-sitosterol glucoside, stigmasterol glucoside, isofucosterol glucoside, taraxsterol, -taraxsterol and their esters, calenduloside A, B, E, F, G and H. Calenduloside B showed antiulcer, antiinflammatory and neurotropic activities (Rastogi and Mehrotra, 1991). It was confirmed in additional studies that these extracts contain compounds with antimicrobial activity against Staphylococcus aureus (Gora et al, 1980;Kasprzyk and Wojciechowski, 1967;Kasprzyk and Pyrek, 1968;Wojciechowski et al, 1972;Swiatek and Gora, 1978;Dumenil et al, 1980). Russian investigators found that sterile preparations of Calendula extracts alleviated the signs of chronic conjunctivitis and other ocular inflammatory conditions in rats; the extracts also had a systemic antiinflammatory effect (Olin, 1992).…”

Section: Discussionmentioning

confidence: 87%

A review of plant species used to treat conjunctivitis

Sharma

Singh

2002

Phytotherapy Research

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Conjunctivitis is a major occular external infection in tropical countries. Although not a very serious disease, it gives much discomfort and sometimes leads to partial blindness or blindness due to corneal involvement. Conjunctivitis has been known to occur in epidemic proportions in different parts of the world, mainly African and Asian regions. The indigenous cure of conjunctivitis using herbal products has been popular for centuries. This paper is an attempt to compile information on plants mentioned as a cure for conjunctivitis during ethnobotanical surveys between 1933 and 2000. Plants mentioned as a cure in various systems of medicine, namely Siddha and Ayurveda, are also included.

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Section: Discussionmentioning

confidence: 87%

A review of plant species used to treat conjunctivitis

Sharma

Singh

2002

Phytotherapy Research

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“…Moreover, in some representatives of both series a single glucose molecule is attached also to the carboxyl group of oleanolic acid, thus creating bidesmosides. The structure of compounds from both series of oleanolic acid glycosides occurring in C. officinalis was established at Department of Plant Biochemistry, Warsaw University (Kasprzyk and Wojciechowski, 1967;Wojciechowski et al, 1971). ''Glucuronides'', known as the series I, were designated with letters (F, D, D 2 , C, B, A) and ''glucosides'', forming the series II -with subsequent Roman numerals from I to VIII.…”

Section: Introductionmentioning

confidence: 99%

Saponins in Calendula officinalis L. – Structure, Biosynthesis, Transport and Biological Activity

2005

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Trends in research on Calendula officinalis L. saponins performed in Department of Plant Biochemistry at Warsaw University are reviewed. Calendula officinalis, a well known medicinal plant, contains significant amounts of oleanane saponins, which form two distinct series of related compounds, called ''glucosides'' and ''glucuronides'' according to the structure of the respective precursor. Both series differ in the pathway of their biosynthesis and further metabolism, i.e. the rate of formation and stages of possible degradation; distribution in the single cell and in the whole plant, including accumulation sites; and the possible physiological role played in the plant according to appropriate biological activities.

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“…Flowers and shoots of pot marigold contain six structurally related saponins (Kasprzyk and Wojciechowski, 1967;Kintia et al, 1974;Vidal-Ollivier et al, 1989) which are monoor bidesmosidic derivatives of oleanolic acid containing up to four monosaccharide moieties (Figure 3a). Our in vivo studies of the dynamics of labeling of the individual saponins with [2) 14 C]mevalonate (Kintia et al, 1974) indicated that their synthesis proceeds, most probably, by the stepwise elongation of carbohydrate moiety, i.e.…”

Section: Triterpene Saponinsmentioning

confidence: 98%

The Formation of Sugar Chains in Triterpenoid Saponins and Glycoalkaloids

et al. 2005

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Triterpenoid saponins and structurally related steroidal glycoalkaloids are a large and diverse family of plant glycosides. The importance of these compounds for chemical protection of plants against microbial pathogens and/or herbivores is now well-documented. Moreover, these compounds have a variety of commercial applications, e.g. as drugs or raw materials for pharmaceutical industry. Until recently there were only sparse data on the biosynthesis of saponins and glycoalkaloids, especially at the enzyme level. Substantial progress has recently been made, however, in our understanding of biosynthetic routes leading to the formation of the diverse array of aglycone skeletons found in these compounds as well as mechanisms of synthesis of their sugar moieties. This review highlights some of the advances made over past two decades in our understanding of the formation and modification of sugar moieties in triterpenoid saponins and glycoalkaloids.

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The structure of triterpenic glycosides from the flowers of Calendula officinalis L.

Cited by 54 publications

References 0 publications

A review of plant species used to treat conjunctivitis

A review of plant species used to treat conjunctivitis

Saponins in Calendula officinalis L. – Structure, Biosynthesis, Transport and Biological Activity

The Formation of Sugar Chains in Triterpenoid Saponins and Glycoalkaloids

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