The Study About Physical Activity for Subjects With Prevention of Benign Prostate Hyperplasia

Abstract

PurposeThe number of benign prostatic hyperplasia (BPH) subjects has been increasing worldwide, and many studies have been conducted to determine the treatment that can delay drug therapy or surgery. Subsequently, most of these studies involved physical activity (PA) and associated factors. Therefore, we aimed to determine factors associated with BPH prevalence based on a review of past and present studies and to investigate the effect of a healthy lifestyle as a protective factor of BPH occurrence.MethodsWe selected 582 subjects aged ≥40 years from an initial 779 subjects recruited from Gyeonggi, Yangpyeong, South Korea, during August 2009 to August 2011. Trained investigators surveyed International Prostate Symptom Score and demographic information, including PA and lifestyle questionnaire during face-to-face interviews; further, they performed digital rectal examination, rectal ultrasonography, and measured prostate-specific antigen levels. The statistical association between PA and BPH was analyzed by logistic regression analysis using multivariable regression models which use categorical variables by the Cochran-Mantel-Haenszel test and continuous variables by the general linear model.ResultsSeven statistically significant variables for PA were selected. Regular exercise, frequency of exercise, sedentary time, nonsedentary time, leisure time PA (metabolic equivalent, hr/wk) were not statistically associated with prostate volume but sedentary time (hr/day) was the only factor that showed a significant association in the multivariable model, including a linear effect relationship. Subjects with lower levels of sedentary time (4.5-7.0 hr/day) had a significantly lower risk of BPH (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.52-1.67) than those with a higher sedentary time (>7 hr/day) (OR, 1.72; 95% CI, 0.96-3.09) (P for trend=0.05).ConclusionsOur study showed that reducing sedentary time could have a protective effect and reduce the prevalence of BPH. Further prospective studies with a larger sample size are needed to assess the impact of reducing sedentary time on BPH risk.

Incidence of benign prostate hypertrophy in Danish men with and without HIV infection

“…In addition, studies have identified several risk factors associated with an increased risk of BPH, including cardiovascular risk factors, a prior history of STDs (especially gonorrhoea), metabolic syndrome, chronic inflammation and sedentary activity [10,15,13,29,30]. HIV-infected men are at a higher risk of contracting STDs, which could be expected to translate into an increased risk of BPH [17,19,31].…”

Aerobic exercise regulating expression of ERá and ERâ in prostate to prevent benign prostatic hyperplasia of obesity mice

“…A recent meta-analysis, containing 19 studies, reports a positive association between Body Mass Index (BMI) and Lower urinary tract syndrome (LUTS) related to BPH (odds ratio (OR) = 1.28%) (Wang, Mao et al 2012). Many investigations have shown that obese men have a higher risk of BPH (Wang, Hsieh et al 2011, Corona, Vignozzi et al 2014 and proved that the impact on male aging can be halted by aerobic exercise (Brown and Emberton 2009, Poon and McVary 2009, Jung, Lee et al 2012, Lee, Kim et al 2014.…”

Understanding patient and physician perceptions of benign prostatic hyperplasia in Asia Pacific, Latin America and the Commonwealth of Independent States: the Prostate Research on Behaviour and Education ( PROBE ) II survey

“…Benign prostatic hyperplasia (BPH) is common among older men, with 612 million cases predicted to occur by 2018 1, 2. Histologically, BPH is defined as the presence of stromal‐glandular hyperplasia within the prostate gland 3.…”

“…Benign prostatic hyperplasia (BPH) is common among older men, with 612 million cases predicted to occur by 2018. 1,2 Histologically, BPH is defined as the presence of stromal-glandular hyperplasia within the prostate gland. 3 Many patients with BPH present with bothersome lower urinary tract symptoms (LUTS), typically an increase in urinary urgency and frequency, nocturia, decreased and intermittent force of stream and a sense of incomplete bladder emptying 3 ; these symptoms can have a substantial negative impact on quality of life (QoL).…”