The study and comparative analysis of GerdQ and GSRS Questionnaires on gastroesophageal reflux disease diagnostics

Abstract

Introduction: Clinical questionnaires have some limitations compared to instrumental diagnosis of gastroesophageal reflux disease (GERD), but clinical diagnosis of GERD based on typical symptoms is pragmatic and well-established by societal guidelines.Aim: To study the diagnostic value and provide comparative analysis of GerdQ and GSRS questionnaires regarding the GERD diagnostics based on a comparison of the questionnaires with the results of intraluminal oesophageal impedance-pH monitoring in Ukraine.Material and methods: Twenty-eight patients (11 men and 17 women with a mean age of 47 ±2.4 years and a mean body mass index of 25.6 ±1.1 kg) filled in the GerdQ and GSRS questionnaires and underwent 24-hour multichannel intraluminal oesophageal impedance-pH monitoring.Results: The GerdQ questionnaire showed a significantly strong correlation between the total score of the questionnaire and the key indicators of 24-hour impedance-pH monitoring: AET (r s = 0.793), acid reflux episodes (r s = 0.796), and liquid reflux episodes (r s = 0.730). Correlation of reflux syndrome according to the GSRS questionnaire was established between the acid reflux episodes (r s = 0.530), the episodes of all fluid refluxes (r s = 0.598), and AET (r s = 0.560), but the strength of the correlation relationships is weaker. The GerdQ questionnaire showed a sensitivity of 78.6%, specificity of 92.9%, and accuracy (diagnostic efficiency) of 85.7%.Conclusions: The use of the GerdQ questionnaire for the diagnosis of GERD is optimal in everyday practice for deciding whether to prescribe "ex juvantibus" therapy or whether to use instrumental examination methods (upper endoscopy, oesophageal pH monitoring, oesophageal impedance-pH monitoring).

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Bulgaria: An Internet-Based Survey

“…We have also to add that the GORD questionnaires were validated and approved for everyday clinical practice as a reliable tool for GORD diagnosis and for therapy and follow-up management of the patients [38, 39]. The sensitivity of GORD questionnaire was estimated as 78.6% and specificity as 92.9% and accuracy (diagnostic efficiency) as 85.7% [40]; and sensitivity between 62 and 67% and specificity of 63–70% assessed by the Diamond study [41].…”

Associations of Clinical Characteristics and Intestinal Flora Imbalance in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients and the Construction of an Early Warning Model

“…Gastrointestinal Symptom Rating scale (GSRs) scores 14 included abdominal pains (abdominal pain, nausea, vomiting), reflux (heartburn, belching, acid reflux), diarrhea (fecal diarrhea, incontinence, and urgency), dyspepsia (abdominal ringing and distension, increased exhaustion), and constipation (infrequent defecation, stool tumor, incomplete defecation). Each symptom score ranged from 0 to 3.…”

“…Compared with the control, the case group had a lower BMI, worse pulmonary function, lower arterial oxygen partial pressure, and albumin concentration (p < 0.05). The median CAT scores of the case and control groups were 14 (9,19) and 9 (7,14), respectively. The median mMRC score was 2 (1, 3) for the control and 1 (0, 2) for the case group.…”

Consenso latinoamericano de diagnóstico de la enfermedad por reflujo gastroesofágico

“…En general, los pacientes con ERGE demostrada tienden a tener puntuaciones más altas, pero muchos pacientes con esofagitis tienen puntuaciones bajas. 25,[27][28][29][30][31][32][33] Un estudio multicéntrico en China investigó la utilidad del cuestionario GerdQ en 8065 pacientes con síntomas gastrointestinales superiores a los que se les había realizado una EGD. 27 En todos los pacientes, el cuestionario GerdQ fue aplicado antes de la EGD.…”

“…En Europa oriental, en un pequeño estudio que incluyó a 28 pacientes, se evaluaron los cuestionarios GerdQ y GSRS para el diagnóstico de la ERGE, comparados con la pH-impedancia esofágica (MII-pH). 31 El cuestionario GerdQ mostró una correlación estadísticamente significativa entre la puntuación total del cuestionario, el TEA, el número de episodios de reflujo ácido y el número de episodios de reflujo líquido. La sensibilidad, la especificidad y la precisión diagnóstica fueron del 78,6%, 92,9% y 85,7%, respectivamente.…”