The study of acute and chronic toxicity of the sodium-, calcium-, iron-polygalacturonate pharmacological substance in rabbits

Минзанова, С. Т.; Miluykov, Vasili; Krayushkina, A. V.; Arkhipova, D. M.; Vyshtakalyuk, A.В.; Миронова, Л. Г.; Миронов, В. Ф.; Папуниди, К Х; Semenov, Eduard I.; Kadikov, Ilnur R.; Sinyashin, Оleg G.

doi:10.1016/j.toxrep.2018.03.011

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…This investigation work was carried out at a high level, which is confirmed by the data of the modern scientific literature describing similar studies [ 3 , 18 – 20 , 22 , 23 ]. The obtained findings have an important significance as they confirm the toxicological safety of the dental gel and allow us to recommend it for further clinical trials as a tool of dental therapy.…”

Section: Resultssupporting

confidence: 73%

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Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice

Badekova,

Atazhanova,

Losseva

et al. 2023

Journal of Toxicology

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Objectives. The creation of new herbal medicines for their use in dentistry is relevant. The purpose of this work is to study the acute toxicity of the anticaries dental gel (ACDG3) developed by us based on Origanum vulgare. Results. In case of studying the safety of anticaries dental gel “ACDG3” in animals, that with a single dose of up to 2000 mg/kg, the absence of pathological changes in the behavior of animals was noted. Biochemical studies indicate that the studied doses of dental gel did not lead to significant deviations in the blood parameters of mice and deviations fluctuated within the reference values. According to the results of a morphometric study conducted 15 days after the administration of the drug, no deviations were found. The histological evaluation of organs showed little change in the cardiac architecture in animals treated with ACDG3 at doses of 1000 mg/kg and 2000 mg/kg. On the other hand, no significant changes in the cardiac function were observed in all treated mice. Conclusion. As follows from the results obtained, in case of determining acute toxicity, the studied anticaries gel, ACDG3, showed low toxicity. For mice, LD50 was 2000 mg/kg intragastrically. So, according to the generally accepted classification of the toxicity of substances, ACDG3 can be attributed to the class of low-toxic substances (IV class of toxicity, LD50 > 5000 mg/kg, intragastric administration), that is, to practically nontoxic compounds.

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Section: Resultssupporting

confidence: 73%

“…The study of acute toxicity of the drug during preclinical investigation is an essential step in the drug development process [ 23 ]. According to the data of this study, the application of the new dental gel on mice of both genders in doses from 500 to 2000 mg/kg does not cause toxicity.…”

Section: Resultsmentioning

confidence: 99%

Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice

Badekova,

Atazhanova,

Losseva

et al. 2023

Journal of Toxicology

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“…The reaction to the test feed additive was monitored immediately after its use and during the next 14 days. The criteria to assess acute toxicity were feed intake, the clinical picture of intoxication, the number of died animals, the time of their death, and diagnostic autopsy of individual animals [12].…”

Section: Methodsmentioning

confidence: 99%

Toxicological safety assessment of ZeolFat energy feed additive

et al. 2020

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Development of inexpensive and environmentally friendly feed additives based on waste from the food industry and expired products as energy sources for animals is of current relevance and high demand. The study aimed to test the toxicological safety of ZeolFat energy feed additive (EFA) on laboratory animals. The tests on white rats showed that ZeolFat EFA is a low-toxic feed product with no cumulative properties revealed. The animals exhibited satisfactory physical state and a good appetite during experimental feeding. They were active, and their response to external stimuli remained similar to that before EFA introduction. ZeolFat EFA had a stimulating effect on carbohydrate and lipid, and mineral metabolism in rats, thereby ensuring a high increase in their live weight.

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“…Numerous inprogress clinical trials research the possibility of using pectins as a matrix of drug delivery for the treatment of colorectal cancer 12 . High bioavailability of Fe and anti-anemic properties are shown for pectin complexes -Na, Fepolygalac-turonate, and Na, Ca, Fe polygalacturonate and for the latter there is no antagonism between Fe and Ca 13 and absence of toxicity 14 . From the foregoing, we can expect that the complexation of ASA with pectin can lead to both an increase and a decrease in biological activity due to changes in bioavailability, as well as to the manifestation of new properties.…”

Section: Inmentioning

confidence: 99%

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2020

IJPSR

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The aim of this work is a comparison of antiinflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties. INTRODUCTION: Studies in the development of anti-inflammatory drugs confirm their high relevance and take place in novel world literature 1, 2 .

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The study of acute and chronic toxicity of the sodium-, calcium-, iron-polygalacturonate pharmacological substance in rabbits

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Cited by 7 publications

References 20 publications

Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice

Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice

Toxicological safety assessment of ZeolFat energy feed additive

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