The study of biological activity of mandelic acid and its alkali metal salts in wastewaters

Matejczyk, Marzena; Ofman, Piotr; Świsłocka, Renata; Parcheta, Monika; Lewandowski, W.

doi:10.1016/j.envres.2021.112429

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…It can be seen from Figure 5 that the OTMs of the six wastewater samples were significantly higher than those of the control, indicating that each sample caused significant DNA damage to the E. gracilis [ 34 , 35 , 36 ]. Similarly, the study found, using the Comet assay, that organic extracts from Taihu Lake can induce DNA damage on microalgae cells [ 37 , 38 , 39 ]. The genotoxicity of the wastewater samples was J > T > W, and the effluents showed decreases in genotoxicity by 41.06%, 36.12% and 37.15%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Using a Battery of Bioassays to Assess the Toxicity of Wastewater Treatment Plant Effluents in Industrial Parks

Yang

Cui

Gao

et al. 2023

Toxics

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Bioassays, as an addition to physico-chemical water quality evaluation, can provide information on the toxic effects of pollutants present in the water. In this study, a broad evaluation of environmental health risks from industrial wastewater along the Yangtze River, China, was conducted using a battery of bioassays. Toxicity tests showed that the wastewater treatment processes were effective at lowering acetylcholinesterase (AChE) inhibition, HepG2 cells’ cytotoxicity, the estrogenic effect in T47D-Kbluc cells, DNA damage of Euglena gracilis and the mutagenicity of Salmonella typhimurium in the analyzed wastewater samples. Polycyclic aromatic hydrocarbons (PAHs) were identified as potential major toxic chemicals of concern in the wastewater samples of W, J and T wastewater treatment plants; thus, the potential harm of PAHs to aquatic organisms has been investigated. Based on the health risk assessment model, the risk index of wastewater from the industrial parks along the Yangtze River was below one, indicating that the PAHs were less harmful to human health through skin contact or respiratory exposure. Overall, the biological toxicity tests used in this study provide a good basis for the health risk assessment of industrial wastewater and a scientific reference for the optimization and operation of the treatment process.

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Section: Resultsmentioning

confidence: 99%

Using a Battery of Bioassays to Assess the Toxicity of Wastewater Treatment Plant Effluents in Industrial Parks

Yang

Cui

Gao

et al. 2023

Toxics

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“…Bismerthiazol and thiadiazole copper are widely utilized bactericides that have demonstrated efficacy in efficiently managing citrus canker . Mandelic acid, an α-amino acid, possesses significant antibacterial properties and is regarded as a promising substrate and intermediary for the development and synthesis of innovative drugs. , The utilization of mandelic acid and its derivatives is prevalent in the fields of medicines, aesthetic medicine, and environmental therapy. , Furthermore, there have been reports in the field of agriculture indicating that they possess the ability to effectively minimize the occurrence of black shank . Although all of the aforementioned compounds possess antiseptic properties, it is possible to develop and synthesize their active structural frameworks using novel methodologies in order to acquire the desired molecules.…”

Section: Introductionmentioning

confidence: 99%

“…36,37 The utilization of mandelic acid and its derivatives is prevalent in the fields of medicines, aesthetic medicine, and environmental therapy. 38,39 Furthermore, there have been reports in the field of agriculture indicating that they possess the ability to effectively minimize the occurrence of black shank. 40 Although all of the aforementioned compounds possess antiseptic properties, it is possible to develop and synthesize their active structural frameworks using novel methodologies in order to acquire the desired molecules.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Mandelic Acid Derivatives for Suppression of Virulence via T3SS against Citrus Canker

Zhang,

Wang,

Shi

et al. 2024

J. Agric. Food Chem.

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Citrus canker, a highly contagious bacterial disease caused by Xanthomonas citri subsp. citri (Xcc), poses a substantial threat to citrus crops, leading to serious reductions in fruit yield and economic losses. Most commonly used bactericides against Xcc lead to the rapid development of resistant subpopulations. Therefore, it is imperative to create novel drugs, such as type III secretion system (T3SS) inhibitors, that specifically target bacterial virulence factors rather than bacterial viability. In our study, we designed and synthesized a series of mandelic acid derivatives including 2-mercapto-1,3,4-thiazole. Seven substances were found to reduce the level of transcription of hpa1 without affecting bacterial viability. In vivo bioassays indicated that compound F9 significantly inhibited hypersensitive response and pathogenicity. RT-qPCR assays showed that compound F9 visibly suppressed the expression of Xcc T3SS-related genes as well as citrus canker susceptibility gene CsLOB1. Furthermore, the combination with compound F9 and quorum-quenching bacteria HN-8 can also obviously alleviate canker symptoms.

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“…There are many compounds of natural origin with high biological activity. One of them is mandelic acid, which, due to its biological properties, has been used in the cosmetics and pharmaceutical industries [ 5 , 6 , 7 ]. Mandelic acid (MA) and its derivatives are an essential class of chemical compounds widely used in drug synthesis and stereochemistry research.…”

Section: Introductionmentioning

confidence: 99%

Research on the Electron Structure and Antimicrobial Properties of Mandelic Acid and Its Alkali Metal Salts

Świsłocka

Świderski

Nasiłowska

et al. 2023

IJMS

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This article investigated the structure, and the spectroscopic and antimicrobial properties of mandelic acid and its alkali metal salts. The electron charge distribution and aromaticity in the analyzed molecules were investigated using molecular spectroscopy methods (FT-IR, FT-Raman, 1H NMR, and 13C NMR) and theoretical calculations (structure, NBO, HOMO, LUMO, energy descriptors, and theoretical IR and NMR spectra). The B3LYP/6-311++G(d,p) method was used in the calculations. The antimicrobial activities of mandelic acid and its salt were tested against six bacteria: Gram-positive Listeria monocytogenes ATCC 13932, Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633, and Loigolactobacillus backii KKP 3566; Gram-negative Escherichia coli ATCC 25922 and Salmonella Typhimurium ATCC 14028, as well as two yeast species, Rhodotorulla mucilaginosa KKP 3560 and Candida albicans ATCC 10231.

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The study of biological activity of mandelic acid and its alkali metal salts in wastewaters

Cited by 7 publications

References 29 publications

Using a Battery of Bioassays to Assess the Toxicity of Wastewater Treatment Plant Effluents in Industrial Parks

Using a Battery of Bioassays to Assess the Toxicity of Wastewater Treatment Plant Effluents in Industrial Parks

Design and Synthesis of Mandelic Acid Derivatives for Suppression of Virulence via T3SS against Citrus Canker

Research on the Electron Structure and Antimicrobial Properties of Mandelic Acid and Its Alkali Metal Salts

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