The study of clinical, biochemical and hematological profile in malaria patients

Khuraiya, Prashant; Sharma, Shiv Shankar; Thakur, Ashok Singh; Pandey, Vijayendra; Verma, Shaily

doi:10.18203/2349-3933.ijam20160685

Cited by 9 publications

(20 citation statements)

References 7 publications

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“…Near similar values are observed in Khuraiya P et al, study group and Kalavati GP et al, study group which includes 6% and 5.7% respectively. 9,11 The predominant age group affected is working age group which is because, this age group is commonly exposed to mosquito bites mainly in fields and outdoors and also our the study follows the age pyramid in our country which shows young people form the base and older people form the apex which contains a lesser percentage of the population.…”

Section: Discussionmentioning

confidence: 58%

“…A similar observation like fever as presenting complaint and presence of fever in 100% of patients is present in Khuraiya P et al, study, Patel G et al, study and Anshika Jain et al, study group. 9,10,13 In Rathod SN et al, study fever was present in 95.1% of patients. 14 In Another study group Surve KM et al, fever was present in 99% of the patients.…”

Section: Discussionmentioning

confidence: 95%

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Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

et al. 2020

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Background: Malaria is a major health problem in many parts of India and some parts of Andhra Pradesh is one of the endemic areas for malaria. The objective was to study clinical profile and outcome of malaria in both species and mixed infection.Methods: Present study was carried out on 100 patients admitted during the period of November 2016 - October 2018 in Narayana medical college and hospital, Nellore. Malaria confirmed by Peripheral thick and thin smear or Antigen Assay underwent detailed clinical history and physical examination. This was followed by monitoring the outcome of the patients with respect to morbidity and mortality.Results: Out Of the 100 patients 58 patients were from rural background, males were predominant, most common age group was 20-30 (34%) followed by 31-40 (31%). Out of 100 patients, 54 patients were falciparum,44 patients had vivax and two had mixed infection. All of the patients had fever followed by chills and rigors (75%), nausea and vomiting (59%), easy fatiguability (28%), pain abdomen (17), cough (14%) in both infections, altered sensorium was seen in only falciparum (20.3%). On clinical examination,70% of the patients had pallor, splenomegaly in 46%, icterus (23%), hepatomegaly (14%) and pedal edema in12 patients were observed. All 0f the patients were treated with appropriate antimalarial drugs for appropriate duration, and all were recovered without any mortality.Conclusions:Malaria is very common disease in our country especially in South India, which is one of the endemic areas. Severe malaria usually caused by the falciparum more than vivax, early diagnosis and treatment decreases the mortality and morbidity.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 95%

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

et al. 2020

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“…This is caused by vascular congestion and reticuloendothelial proliferations. 28 Anemia is frequent presenting features of malaria and it was observed in 66.03% cases which are quite higher than observed in another study. 22 However, similar result was observed in two Indian studies conducted by Hussain et al who found higher prevalence of anemia in (60.52%) falciparum malaria patients and another study from central India (M.P) reported that 57% patients had normocytic normochromic anemia.…”

Section: Discussionmentioning

confidence: 58%

“…The outcomes of present study are agreed with a case control study performed by Khuraiya et al in central (M. P) India. 28 This is because of delay in referral services and high level of parasitaemia in blood.…”

Section: Discussionmentioning

confidence: 99%

“…22 However, similar result was observed in two Indian studies conducted by Hussain et al who found higher prevalence of anemia in (60.52%) falciparum malaria patients and another study from central India (M.P) reported that 57% patients had normocytic normochromic anemia. 28,29 The pathogenesis of anemia is complex and multifactorial. The mechanism is destruction of parasitized red blood cells, malaria antigen attachment to erythrocytes followed by their immunological lysis and destruction of newly synthesized erythrocytes by TNF.…”

Section: Discussionmentioning

confidence: 99%

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Study of clinical presentation of falciparum malaria and correlation with laboratory indices of poor prognosis

Choudhary¹,

Choudhary

2017

Int J Adv Med

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Background: Severe malaria is a chief cause of death in the North-eastern states of India. The criteria for defining severe malaria have fluctuating over the last many years. Detection of both specific and sensitive clinical features of falciparum malaria to predict death is required to improve clinical management. Therefore, the objective of present study was designed to investigate the clinical presentation of falciparum malaria and correlation with laboratory indices of poor prognosis.Methods: This prospective observational study was conducted at the R N T Medical College Udaipur, India. Total 53 malarial patients who tested positive for plasmodium falciparum were included. A detailed clinical presentation, haematological and biochemical variables were scrutinized. SPSS-16 software was used for statistical analysis.Results: Out of 53 patients, 6 (11.3%) patients had (>5%) parasitaemia, 3 (5.66%) patients had schizonts in peripheral blood film, 2 (3.77%) patients had serum creatinine >3.0 mg%, 4 (7.54%) patients had raised SGOT and SGPT and all have been died while 11 (20.75%) patients had haemoglobin <7.1 gm% and amongst these 3 (27.27%) patients were died. Out of 53 patients, 13 patients (24.53%) died. Most of the patients had over lapping features with anemia (13.32%), ARDS, 16.98 %, Jaundice 9.43% and impaired consciousness (32.96%). These four features were responsible for high incidence of mortality in malaria.Conclusions: Decisively 29 (54.71%) patients were having laboratory indices of poor prognosis and amongst them 19 (65.51%) patients were died. Therefore, our findings confirm that patients who had P. falciparum malaria with laboratory indices of poor prognosis had high incidence of mortality.

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A comparative study assessing the effect of haematological and biochemical parameters on the pathogenesis of malaria

2019

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The study of clinical, biochemical and hematological profile in malaria patients

Cited by 9 publications

References 7 publications

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

Study of clinical presentation of falciparum malaria and correlation with laboratory indices of poor prognosis

A comparative study assessing the effect of haematological and biochemical parameters on the pathogenesis of malaria

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