The study of different dosages of remazolam combined with sufentanil and propofol on painless gastroscopy: A randomized controlled trial

Abstract

Background: Gastroscopy is one of the most commonly used diagnostic modalities for upper gastrointestinal disorders. Remazolam besylate, a new type of ultrashort-acting benzodiazepine drug, has been less studied in gastroscopy. In this study, we studied the efficacy and safety of remazolam combined with propofol for painless gastroscopy. Methods: This is a single-center, randomized controlled clinical trial. Hundred patients undergoing painless gastroscopy were included in this study and randomly divided into 2 groups (n = 50 per group): the remazolam 3 mg group (R3 group) and the remazolam 6 mg group (R6 group). Sufentanil, remazolam, and propofol are used to anesthetize the patients, and then, the effects of different dosages of remazolam on these patients are compared and analyzed. The patient’s general condition, vital signs at different times, the dosage of propofol (mg) and additional times, complications, duration of gastroscopy (minute), awakening time (minute), residence time in the resuscitation room (minute), and adverse reactions were recorded. Results: R3 group systolic blood pressure and diastolic blood pressure are more stable (P < .05); The number of additional propofol in R6 group was less (P < .05). The incidence of hypotension was lower in R3 group, as well as the time of awakening and staying in the resuscitation room were shorter (P < .05). Conclusion: Remazolam 3mg combined with sufentanil and propofol have less effect on hemodynamics in painless gastroscopy, and the patients have shorter awakening time.

Remimazolam inhibits cough during emergence from general anesthesia in thyroid surgeries

“…remimazolam is a promising anesthetic agent for clinical application 23 . Wu et al 24 found that remimazolam produces a low rate of circulatory inhibition and it is e cacy and safe in painless gastroscopy, painless colonoscopy, beroptic bronchoscopy and abortion surgery. Remimazolam likely increases the tolerance to the endotracheal tube by its sedative effect ,thus reduce the throat response to extubation,similar to dexmedetomidine.…”