The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry

Cho, Yi‐Tzu; Su, Hung; Wu, Chieh‐Shan; Jeng, Jingyueh; Lee, Chi‐Wei; Wu, Deng‐Chyang; Huang, Tiao‐Lai; Shiea, Jentaie

doi:10.38212/2224-6614.3413

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Both AIMS approaches allow a high sample throughput (≤ 5 s from collection to data generation (Cho et al, 2021 ; Zhao et al, 2008 ) but do not allow molecular separation prior to detection. Considering the successes of AIMS for biological skin analyses in forensic science (Justes et al, 2007 ; Zhao et al, 2008 ), drug development (Cho et al, 2022 ; Katona et al, 2011 ), and cosmetic science (Motoyama & Kihara 2017 ), as well as continuous developments regarding probes (Fatou et al, 2018 ; Meisenbichler et al, 2020 ; Shamraeva et al, 2022 ) and portable mass spectrometers (Burns et al, 2022 ; Hendricks et al, 2014 ; Li et al, 2014 ; Mulligan et al, 2006 ), this is an exciting area to watch. For more information, the following reviews are recommended (Feider et al, 2019 ; Kuo et al, 2020 ).…”

Section: Current Sampling and Extraction Proceduresmentioning

confidence: 99%

No skin off your back: the sampling and extraction of sebum for metabolomics

et al. 2023

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Introduction Sebum-based metabolomics (a subset of “sebomics”) is a developing field that involves the sampling, identification, and quantification of metabolites found in human sebum. Sebum is a lipid-rich oily substance secreted by the sebaceous glands onto the skin surface for skin homeostasis, lubrication, thermoregulation, and environmental protection. Interest in sebomics has grown over the last decade due to its potential for rapid analysis following non-invasive sampling for a range of clinical and environmental applications. Objectives To provide an overview of various sebum sampling techniques with their associated challenges. To evaluate applications of sebum for clinical research, drug monitoring, and human biomonitoring. To provide a commentary of the opportunities of using sebum as a diagnostic biofluid in the future. Methods Bibliometric analyses of selected keywords regarding skin surface analysis using the Scopus search engine from 1960 to 2022 was performed on 12th January 2023. The published literature was compartmentalised based on what the work contributed to in the following areas: the understanding about sebum, its composition, the analytical technologies used, or the purpose of use of sebum. The findings were summarised in this review. Results Historically, about 15 methods of sampling have been used for sebum collection. The sample preparation approaches vary depending on the analytes of interest and are summarised. The use of sebum is not limited to just skin diseases or drug monitoring but also demonstrated for other systemic disease. Most of the work carried out for untargeted analysis of metabolites associated with sebum has been in the recent two decades. Conclusion Sebum has a huge potential beyond skin research and understanding how one’s physiological state affects or reflects on the skin metabolome via the sebaceous glands itself or by interactions with sebaceous secretion, will open doors for simpler biomonitoring. Sebum acts as a sink to environmental metabolites and has applications awaiting to be explored, such as biosecurity, cross-border migration, localised exposure to harmful substances, and high-throughput population screening. These applications will be possible with rapid advances in volatile headspace and lipidomics method development as well as the ability of the metabolomics community to annotate unknown species better. A key issue with skin surface analysis that remains unsolved is attributing the source of the metabolites found on the skin surface before meaningful biological interpretation.

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Section: Current Sampling and Extraction Proceduresmentioning

confidence: 99%

No skin off your back: the sampling and extraction of sebum for metabolomics

et al. 2023

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“…The desorbed analytes are delivered by a nitrogen stream into an electrospray plume located underneath the thermal desorption chamber, where they react with the charged solvent species to form analyte ions . The time required to complete a typical TD-ESI/MS analysis is less than 60 s, so the technique has been applied in rapid detection of various toxicants in biospecimens for emergency care. − …”

Section: Introductionmentioning

confidence: 99%

Rapid Characterization of Undeclared Pharmaceuticals in Herbal Preparations by Ambient Ionization Mass Spectrometry for Emergency Care

Lee,

Su,

Hsu

et al. 2024

J. Am. Soc. Mass Spectrom.

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In Asia, some herbal preparations have been found to be adulterated with undeclared synthetic medicines to increase their therapeutic efficiency. Many of these adulterants were found to be toxic when overdosed and have been documented to bring about severe, even life-threatening acute poisoning events. The objective of this study is to develop a rapid and sensitive ambient ionization mass spectrometric platform to characterize the undeclared toxic adulterated ingredients in herbal preparations. Several common adulterants were spiked into different herbal preparations and human sera to simulate the clinical conditions of acute poisoning. They were then sampled with a metallic probe and analyzed by the thermal desorption-electrospray ionization mass spectrometry. The experimental parameters including sensitivity, specificity, accuracy, and turnaround time were prudently optimized in this study. Since tedious and time-consuming pretreatment of the sample is unnecessary, the toxic adulterants could be characterized within 60 s. The results can help emergency physicians to make clinical judgments and prescribe appropriate antidotes or supportive treatment in a time-sensitive manner.

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“…[4][5][6][7] Various analytical methods for its determination are documented in the literature. Most of these techniques are based on chromatographic methods, [8] including HPLC with UV detection, [9,10] HPLC-MS detection [11,12] and capillary zone electrophoresis. [13] Terbinafine has been determined spectrophotometrically, [14,15] voltammetrically [16] and potentiometrically.…”

Section: Introductionmentioning

confidence: 99%

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

Alterary,

Mostafa,

El‐Tohamy

et al. 2024

ChemistrySelect

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The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes. The content of terbinafine hydrochloride (TRF) in pharmaceutical tablets was determined using a novel coated, wire‐functionalized CaO/ZnO nanocomposite membrane sensor biogenically produced from Lavandula spica extract. Sodium tetraphenylborate was used to prepare the active material (TRF‐TBP). The newly modified sensor gave excellent potentiometric sensitivity with the least squares regression equation EmV=(−58.88X±0.3)+log [TRF]+549.78 and covered a wide linear range (5.0×10−9–1.0×10−2 mol/L) of TRF samples. In contrast, the standard TRF‐TBP sensor wasn't as sensitive when (2.5×10−6–1.0×10−2 mol/L). TRF solutions with regression equation of (−55.728X±0.7)+log [TRF]+396.64. The appropriate pH range was 3–6. The principles of analytical methodology were applied to investigate the validity and suitability of the proposed technique. The proposed sensors were found to be suitable and efficient for the detection of TRF on tablets.

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The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry

Cited by 6 publications

References 28 publications

No skin off your back: the sampling and extraction of sebum for metabolomics

No skin off your back: the sampling and extraction of sebum for metabolomics

Rapid Characterization of Undeclared Pharmaceuticals in Herbal Preparations by Ambient Ionization Mass Spectrometry for Emergency Care

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

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