The Study of Etiologic and Demographic Characteristics of Intracranial Brain Abscess: A Consecutive Case Series Study from Pakistan

Manzar, Nabeel; Manzar, Bushra; Kumar, Rajesh; Bari, Ehsan

doi:10.1016/j.wneu.2011.02.011

Cited by 33 publications

(42 citation statements)

References 19 publications

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“…Abscesses of unknown cause accounted for 54.94% of the subjects, higher than the values reported for other series. [12,39,[41][42][43] In most large series of brain abscesses from developing countries, middle ear infection has been reported to be the most common source of intracranial suppuration, a result similar to the current study. [44] The basic principle of treatment is the prescription of appropriate antibiotics with or without aspiration, treatment of sequelae that is, hydrocephalus, seizures etc., and eradication of primary source.…”

Section: Discussionsupporting

confidence: 90%

“…The mortality rate shown here is similar to the rates observed by other authors, which range between 8% and 53%. [54] Manzar et al [43] reported that the most important factors influencing mortality was the neurologic condition of the patient at the time of admission. Here, we found mortality was very high in brain abscess with low GCS score on admission [ Tables 7 and 8].…”

Section: Discussionmentioning

confidence: 99%

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Brain abscess: surgical experiences of 162 cases

Chowdhury¹,

Haque²,

Sarkar³

et al. 2015

Neuroimmunol Neuroinflammation

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Brain abscess: surgical experiences of 162 cases

Chowdhury¹,

Haque²,

Sarkar³

et al. 2015

Neuroimmunol Neuroinflammation

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“…However, in a study carried out by Cavuşoglu H et al , the temporoparietal region was the most commonly affected location [14]. Abscesses of unknown cause accounted for 48.33% of the subjects, a percent higher than the values reported for other series [5-7,10,15]. …”

Section: Resultsmentioning

confidence: 96%

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

Zhang

et al. 2014

BMC Infect Dis

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BackgroundBrain abscesses continue to pose diagnostic and therapeutic challenges in developed and developing countries. Their aetiology and management remain complex and unclear, making improvement of treatments and outcome difficult.MethodsTo determine the demographics, management, and the variables that affect the outcome in subjects with brain abscesses treated at a single centre over an 11-year period, we retrospectively analysed data in 60 patients with brain abscesses surgically treated with stereotactically guided aspiration or open craniotomy excision in Shanghai Changzheng Hospital between January 2001 and December 2011. Such variables as age, gender, Glasgow Coma Scale (GCS) score at admission, clinical presentation, location, number of lesions, predisposing factors, mechanism of infection, aetiological agent, and therapy were analysed independently.ResultsOur analysis demonstrated that patient age and gender were factors that influence the occurrence of brain abscess; female patients and patients greater than 40 years of age were most likely to suffer a brain abscess. We also found that a patient’s GCS score upon admission did not influence outcome. While frequency of successful culturing of the infectious agent was low, positive cultures were obtained in only 8 of the cases (13.33%), in which the most common isolate was Streptococcus milleri. Outcome was favourable in 78.33% of the subjects, while the mortality rate was 20%. The outcome of one patient was poor due to the abscess in the basal ganglia region.ConclusionsStereotactically guided aspiration is an effective treatment for brain abscess with an overall favourable outcome. Mortality due to brain abscess was not directly related to surgery nor surgical technique. Additional studies will continue to reveal patients trends that may improve treatment for brain abscess.

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“…La cefalea es el síntoma más significativo por su intensidad y persistencia, la fiebre aparece solamente en la mitad de los casos. La signología meníngea, el edema de papila o las crisis convulsivas están presentes en 25% 5,6 . El desarrollo de meningitis es frecuente, sin embargo, la mayoría de los abscesos son solitarios y tienen preferencia por el lóbulo frontal 5,6 .…”

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“…La signología meníngea, el edema de papila o las crisis convulsivas están presentes en 25% 5,6 . El desarrollo de meningitis es frecuente, sin embargo, la mayoría de los abscesos son solitarios y tienen preferencia por el lóbulo frontal 5,6 . Los déficits focales se relacionan con la ubicación, el tamaño y el número de lesiones 1,6 .…”

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