The study of human heredity : methods of collecting, charting and analyzing data / by Charles B. Davenport ... [et al.]

Davenport, Charles Benedict

doi:10.5962/bhl.title.35242

Cited by 18 publications

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“…Reported to antagonize CysLT 1 receptor signalling in vivo and in vitro [1175]. See reviews [250] and [396]. GPR20 GPR21 GPR22 GPR25 GPR26 HGNC, UniProt GPR20, Q99678 GPR21, Q99679 GPR22, Q99680 GPR25, O00155 GPR26, Q8NDV2…”

Section: 1-84) [344]mentioning

confidence: 99%

“…Another group instead proposed that GPR17 functions as a negative regulator of the CysLT 1 receptor response to leukotriene D 4 (LTD 4 ). For further discussion, see [396]. Reported to antagonize CysLT 1 receptor signalling in vivo and in vitro [1175].…”

Section: 1-84) [344]mentioning

confidence: 99%

“…GPR4, GPR65, GPR68 and GPR132 are now thought to function as proton-sensing receptors detecting acidic pH [396,1704]. Gene disruption is associated with increased perinatal mortality and impaired vascular proliferation [2085].…”

Section: Commentsmentioning

confidence: 99%

“…Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [530], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [396]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs.…”

mentioning

confidence: 99%

“…a Numbers in brackets refer to orphan receptors for which an endogenous ligand has been proposed in at least one publication, see [396]; b [1443]; c [1309]; d [1866].…”

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confidence: 99%

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The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

Alexander

Davenport

Kelly

et al. 2015

British J Pharmacology

518

249

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The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/ 10.1111/bph.13348/full. G protein-coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates. Conflict of interestThe authors state that there are no conflicts of interest to declare.

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Section: 1-84) [344]mentioning

confidence: 99%

Section: 1-84) [344]mentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

mentioning

confidence: 99%

“…a Numbers in brackets refer to orphan receptors for which an endogenous ligand has been proposed in at least one publication, see [396]; b [1443]; c [1309]; d [1866].…”

mentioning

confidence: 99%

See 3 more Smart Citations

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

Alexander

Davenport

Kelly

et al. 2015

British J Pharmacology

518

249

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The beginnings of the debate between the Mendelians and the Biometricians in psychiatric genetics: David Heron, Karl Pearson, Abraham Rosanoff, and Charles Davenport 1913–1914

Kendler

2021

American J of Med Genetics Pt B

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The world learned of the heated dispute about the methodology of the early works by Davenport and Rosanoff claiming Mendelian transmission patterns for mental handicap and psychiatric illness in a bold headline in the New York Times on Sunday, November 9, 1913: ENGLISH EXPERT ATTACKS AMERICAN EUGENIC WORK. I here focus on the debate surrounding Rosanoff's 1911 study where he presented evidence that the neuropathic constitution, including, among its manifestations, dementia praecox, and manic-depressive illness, was an autosomal recessive trait.The "English expert," David Heron, a student of Pearson's, launched the debate in his 1913 paper which argued that Rosanoff's field work methods were biased, his clinical assessments sloppy, his phenotype far too broad, and his statistical approach flawed.Both Davenport, Rosanoff's mentor, and Rosanoff vigorously defended their methods. Behind this sometimes personal debate was the long simmering controversy about the relative validity of Biometrical genetic (represented by Heron and Pearson) and Mendelian genetic (represented by Rosanoff and Davenport) models for genetic transmission in plants, animals and, especially, humans. A review suggests that most of Heron's criticisms were valid. This episode presages later controversies within psychiatric genetics, for example between twin and linkage researchers in the 1980s and 1990s.

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Pedigrees and Prejudices: Pre-WWII Inherited Disease Classification at the US Eugenics Record Office

Wilson¹

2017

History of Human Genetics

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The study of human heredity : methods of collecting, charting and analyzing data / by Charles B. Davenport ... [et al.]

Cited by 18 publications

References 0 publications

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

The beginnings of the debate between the Mendelians and the Biometricians in psychiatric genetics: David Heron, Karl Pearson, Abraham Rosanoff, and Charles Davenport 1913–1914

Pedigrees and Prejudices: Pre-WWII Inherited Disease Classification at the US Eugenics Record Office

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