The study of hypolipidemic properties of Ginger extract on the model of type 2 diabetes induced by dexamethasone

Кононенко, Н. М.; Чикиткина, В. В.; Sorokina, M. V.; Ostapets, M. O.

doi:10.24959/nphj.17.2184

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydroethanolic ginger extract improved lipid profile and attenuated the increase of plasma glucose in high-fat diet fed male Wistar rats [21]. Aqueous ginger extract inhibited hypertriglyceridemia and reduced atherogenic apolipoprotein-B with a concomitant increase in HDL-cholesterol thus correcting diabetic dyslipidemia in dexamethasone-induced type 2 diabetic rats [22]. The efficacy of ginger powder in controlling blood lipids in diabetic and hyperlipidemic subjects was also reported by Jafarnejad et al, [23] while Rahimlou et al, [24] observed no change in total cholesterol, HDL and LDL cholesterol but there was a marked reduction fasting blood glucose and triglyceride in patients with non-alcoholic fatty liver disease that were given 2g ginger powder capsule daily compared with the placebo group.…”

Section: Introductionmentioning

confidence: 99%

Effect of Raw and Cooked Ginger (<i>Zingiber officinale</i> Roscoe) Extracts on Serum Cholesterol and Triglyceride in Normal and Diabetic Rats

Paulina¹,

Rasaki²,

Veronica³

2018

View full text Add to dashboard Cite

Dyslipidemia is a risk factor of concern in public health even in a state of anomaly in blood glucose level. The effect of different ginger extracts on body lipids has been reported, few scientific studies have documented the effect of raw ginger extracts while the effect of cooked ginger extract (the form in which the spice is commonly consumed) is yet to be explored. This experimental study was therefore designed to determine the effect of raw and cooked ginger extracts on serum triglycerides and total cholesterol in diabetic rats and compare this with that of non-diabetic rats. Fresh ginger rhizomes were washed peeled, washed, wet-milled (without addition of water) and sieved to give the raw extract. A portion of of the extract was boiled for one hour and cooled to give cooked ginger extract. Seventy male albino rats of weight range 155g-195g were divided into 7 groups (n=10) with 3 groups kept as normal or non-diabetic while the remaining 4 groups were rendered diabetic by intraperitoneal administration of 60mg/kg body weight of streptozocin (STZ) to mimic Type 1 diabetes mellitus. These were repeated with another set of seventy rats but diabetes was induced in the 4 diabetic groups here with a 12 week consumption of high-fat diet (HFD) to mimic Type 2 diabetes mellitus. Serum total cholesterol and triglyceride were determined before and after diabetes induction as well as at the 2 nd and 4 th weeks of extracts and diabetic drugs administration using standard methods. Mean data were compared using Least Significant Difference at p≤0.05.Raw and cooked ginger extracts significantly reduced serum total cholesterol and triglyceride in both medium (2 weeks) and long (4 weeks) terms administration in non diabetic rats. In STZ-induced diabetic rats only raw ginger extract lowered these parameters significantly while the cooked extracts and glybenclamide increased these significantly. However, in HFD-induced diabetic rats, raw, cooked ginger extracts and Metformin reduced both serum total cholesterol and triglyceride significantly. Ginger in both raw and cooked forms may therefore be useful in ameliorating hyperlipidemia which commonly associates diabetic state. Human trial is hereby recommended.

show abstract

Section: Introductionmentioning

confidence: 99%