The Study of Low-frequency Ultrasound to Enhance Transdermal Drug Delivery

Cui, Jianguo; Wei, Yingjin; Wang, Hong

doi:10.1109/iccme.2007.4381938

Cited by 4 publications

(4 citation statements)

References 24 publications

(21 reference statements)

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“…Ultrasound also causes bulk fluid streaming and micro-streaming (Cui et al 2007; Lighthill 1987). It has been shown that enhancement of drug delivery through the skin using ultrasound can be due to streaming (Mitragotri et al 1995; Tang et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye

Nabili

Patel

Mahesh

et al. 2013

Ultrasound in Medicine & Biology

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Delivery of sufficient amounts of therapeutic drugs into the eye is often a challenging task. In this study, ultrasound application (frequencies of 400 KHz to 1 MHz, intensities of 0.3–1.0 W/cm2 and exposure duration of 5 min) was investigated to overcome the barrier properties of cornea, which is a typical route for topical administration of ophthalmic drugs. Permeability of ophthalmic drugs, tobramycin and dexamethasone and sodium fluorescein, a drug-mimicking compound, was studied in ultrasound- and sham-treated rabbit corneas in vitro using a standard diffusion cell setup. Light microscopy observations were used to determine ultrasound-induced structural changes in the cornea. For tobramycin, an increase in permeability for ultrasound- and sham-treated corneas was not statistically significant. Increase of 46%–126% and 32%–109% in corneal permeability was observed for sodium fluorescein and dexamethasone, respectively, with statistical significance (p < 0.05) achieved at all treatment parameter combinations (compared with sham treatments) except for 1-MHz ultrasound applications for dexamethasone experiments. This permeability increase was highest at 400 kHz and appeared to be higher at higher intensities applied. Histologic analysis showed structural changes that were limited to epithelial layers of cornea. In summary, ultrasound application provided enhancement of drug delivery, increasing the permeability of the cornea for the anti-inflammatory ocular drug dexamethasone. Future investigations are needed to determine the effectiveness and safety of this application in in vivo long-term survival studies. (E-mail: mnabili@gwu.edu)

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Section: Discussionmentioning

confidence: 99%

Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye

Nabili

Patel

Mahesh

et al. 2013

Ultrasound in Medicine & Biology

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“…In fact, medical researchers have shown that low-frequency ultrasound is effective in enhancing transdermal transport of various molecules [1,10,11,16,17,19]. Within this work, they have demonstrated that the frequencies around 40 kHz have excellent transdermal propagation with minimal heating [17].…”

Section: Related Workmentioning

confidence: 89%

The sound of touch

Mujibiya

Cao

Tan

et al. 2013

Proceedings of the 2013 ACM International Conference on Interactive Tabletops and Surfaces

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Recent work has shown that the body provides an interesting interaction platform. We propose a novel sensing technique based on transdermal low-frequency ultrasound propagation. This technique enables pressure-aware continuous touch sensing as well as arm-grasping hand gestures on the human body. We describe the phenomena we leverage as well as the system that produces ultrasound signals on one part of the body and measures this signal on another. The measured signal varies according to the measurement location, forming distinctive propagation profiles which are useful to infer on-body touch locations and on-body gestures. We also report on a series of experimental studies with 20 participants that characterize the signal, and show robust touch and gesture classification along the forearm.

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“…The main mechanism of action in US‐enhanced drug delivery appears to be cavitation‐induced production of micrometer‐size pores in the surface barrier layer . Ultrasound also causes microstreaming and bulk fluid streaming . Streaming is caused by a reduction in the strength of the US waves due to their absorption and scattering .…”

mentioning

confidence: 99%

“…13,14 Ultrasound also causes microstreaming and bulk fluid streaming. 15 Streaming is caused by a reduction in the strength of the US waves due to their absorption and scattering. 16 Microstreaming is the flow of fluids caused by the application of US.…”

mentioning

confidence: 99%