The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis

Chen, Hai-Xing; Yuan, Ziying; Kl, Wu; Liu, Chen; Mao, Qing-Dong; He, Baoguo; Yuan, Hao

doi:10.1080/00365521.2019.1594355

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…As for the C/T genotype, cancer occurrence risks were correlated with prostate cancer [5]. Similarly, the C/C genotype was reported to be involved in breast cancer [37,38]. In Tunisia, the distribution of these genotypes and allelic frequencies did not highlight any relationship with acute heart failure [39].…”

Section: Discussionmentioning

confidence: 96%

Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tunisian patients with colorectal cancer and liver metastasis

Hazgui

Weslati

Ounissi

et al. 2022

Arch biol sci (Beogr)

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The balance between pro- and anti-inflammatory cytokine expression is essential for an efficient immune response and for the regulation of cancer development and progression. This study analyzed the expression and genetic variation in IL-1?, IL-6 and IL-10 genes and the possible associations with colorectal cancer (CRC) and colorectal liver metastases (CRLM).We examined IL-1?, IL-6 and IL-10 mRNA expression and three gene variants: IL-1? (rs1143627), IL-10 (rs1800872) and IL-6 (rs1800795), in 198 CRC, 65 CRLM patients and 230 controls. Carriers of the C/T genotype of IL-1? (rs1143627) have an increased risk of developing CRC and CRLM. T/T genotype carriers have a higher risk of CRLM incidence. For IL-10 (rs1800872), patients harboring the C/A genotype have a lower risk of CRC and CRLM occurrence. For IL-6 (rs1800795), the C/C genotype heightens the risk of CRLM development. Overall survival analysis showed that carriers of the C/T genotype of IL-1? (rs1143627) have a worse overall survival in CRC patients. It can be concluded that interleukin genetic variants can be used as biomarkers to detect and predict clinical outcomes and prognostic factors for CRC and CRLM.

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Section: Discussionmentioning

confidence: 96%

Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tunisian patients with colorectal cancer and liver metastasis

Hazgui

Weslati

Ounissi

et al. 2022

Arch biol sci (Beogr)

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“…The TGF-β signaling pathway was one of the canonical pathways investigated in CRC development and progression 16,17 ; thus RUNX3 expression disorders have the potential for CRC etiology. 18 Even though previous reports mainly focused on the aberrant methylation of RUNX3, 19,20 polymorphisms related CRC case-control studies remain in a smaller number. 15 Reports of functional polymorphisms on CRC did not include rs7528484 perhaps because our target polymorphism was not a tag SNP.…”

Section: Discussionmentioning

confidence: 99%

A functional polymorphism within the distal promoter of RUNX3 confers risk of colorectal cancer

Wang

Zhu

et al. 2022

Int J Biol Markers

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Background Accumulating evidence has indicated that runt-related transcription factor 3 ( RUNX3) gene polymorphism (rs7528484) is associated with an alimentary system cancer risk. However, the role of rs7528484 in colorectal cancer is still unclear. The present study aimed to explore the association between rs7528484 and colorectal cancer susceptibility in a Chinese Han population. Material and methods We firstly investigated the effect of the polymorphism rs7528484 in distal promoter of RUNX3 polymorphism on colorectal cancer risk in a Chinese Han population comprising 427 colorectal cancer patients and 503 controls. We then carried out a phenotype–genotype association analysis to validate its influence on the adjacent gene RUNX3. Results Logistic regression analysis demonstrated that the T allele of rs7528484 was significantly associated with an increased risk for colorectal cancer occurrence in our case-control study (odds ratio = 1.33; 95% confidence interval = 1.09–1.65; P = 0.005). In stratified analysis, the susceptibility of colorectal cancer in the T allele carriers increased among the smokers, III and IV tumor stage, and at the rectum. Furthermore, the T allele was significantly correlated with lower expression of RUNX3 in vitro. Conclusion In summary, the current case-control and genotype–phenotype study provides convincing evidence that functional RUNX3 polymorphism (rs7528484) is related to colorectal cancer risk and is a plausible marker for the prediction of colorectal cancer.

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The association between IL-1 family gene polymorphisms and colorectal cancer: A meta-analysis

Liu

Zhai

Wang

et al. 2021

Gene

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The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis

Cited by 5 publications

References 31 publications

Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tunisian patients with colorectal cancer and liver metastasis

Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tunisian patients with colorectal cancer and liver metastasis

A functional polymorphism within the distal promoter of RUNX3 confers risk of colorectal cancer

The association between IL-1 family gene polymorphisms and colorectal cancer: A meta-analysis

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