The study of olfactory dysfunction in SARS-CoV-2 variants

Vaira, Luigi Angelo; Boscolo‐Rizzo, Paolo; Quoc, Emily Bui; Bandekela, Patrick; Saussez, Sven; Lechien, Jérôme R.

doi:10.1007/s00405-022-07548-8

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…The smell impairment is the early marker of this viral infection, with the prevalence reaching 50% of cases, and the current research indicate that significant part of patients will have long‐lasting olfactory dysfunctions as a result of this infection 42 . Additional extended observations for prolonged smell impairment related to COVID‐19 are required 43–49 …”

Section: Discussionmentioning

confidence: 86%

“…42 Additional extended observations for prolonged smell impairment related to COVID-19 are required. [43][44][45][46][47][48][49] We have to mention limitations of our study. One can point to a small number of the participants, however, it must be stressed, that in our study, all participants were tested with the objective method for the comparison, not only the selected group, what is usually practiced.…”

Section: Discussionmentioning

confidence: 97%

“… 42 Additional extended observations for prolonged smell impairment related to COVID‐19 are required. 43 , 44 , 45 , 46 , 47 , 48 , 49 …”

Section: Discussionmentioning

confidence: 99%

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Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Tuz-Hrycyna

Rzepakowska

Niemczyk

2023

Laryngoscope Investig Oto

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BackgroundThe comprehensive counseling of patients with olfactory dysfunctions requires accurate diagnosis. The recommendations include subjective assessment. The Questionnaire of Olfactory Disorders (QOD) is a disease‐specific questionnaire for the subjective evaluation of olfactory dysfunctions.MaterialThe study included 54 patients with olfactory dysfunctions, who were recruited to the study group (SG). The other 47 patients without the history of olfactory dysfunction and nasal cavity pathology were voluntarily allocated to the control group (CG). The protocol of the study was introduced to each patient and included: olfactory testing with Sniffin' Stick test, fulfillment of the Polish version of World Health Organization Quality of Life brief questionnaire and completing of the Polish version of the QOD. All participants (101) were invited for refilling the QOD questionnaire after 2 weeks for the test–retest statistics.ResultsThe Polish QOD statements were significantly correlated and met the requirement by having test–retest correlation larger than 0.7. We found that internal consistency of the test measured by Cronbach's alpha coefficient was very high. The mean scores of the QOD test in normosmic SG patients were compared with corresponding scores in normosmic CG patients using U Mann–Whitney test. The analysis revealed statistically significant differences on mean QOD scores for each domains except QOD‐S between both groups.ConclusionsThe Polish version of the QOD demonstrated high rate of the validity and the reliability. This instrument may be widely used in research projects and clinical practice concerning olfactory disorders in Polish patients.Level of EvidenceNA.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

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Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Tuz-Hrycyna

Rzepakowska

Niemczyk

2023

Laryngoscope Investig Oto

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Prevalence of olfactory dysfunction in D614G, alpha, delta and omicron waves: a psychophysical case-control study

Vaira¹,

Lechien²,

Deiana³

et al. 2022

Rhin

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Background: The purpose of this study was to compare the prevalence of olfactory dysfunction (OD) at different stages of the COVID-19 pandemic by evaluating subjects diagnosed with SARS-CoV-2 infection during the Omicron wave with psychophysical tests and comparing the results with those obtained from patients infected during the D614G, Alpha and Delta waves and with those of a control group. Methodology: The study included adult patients diagnosed with SARS-CoV-2 infection. Depending on the time of diagnosis, the subjects were divided into four study groups: D614G; Alpha, Delta and Omicron variant groups. A group of uninfected individuals was used as control. All subjects underwent psychophysical evaluation of the olfactory function with the Connecticut Chemosensory Clinical Research Center olfactory test (D614G and Alpha groups) or the extended version of the Sniffin'Sticks test (Delta, Omicron and control groups). Results: 372 cases (134 D614G group, 118 Alpha group, 32 in Delta group and 88 Omicron group) were recruited and evaluated within 10 days of infection, alongside 80 controls. Patients self-reported olfactory loss in 72.4% of cases in the D614G group, in 75.4% of cases in the Alpha group, in 65.6% of cases in the Delta group and in 18.1% in the Omicron group. Psychophysical evaluation revealed a prevalence of OD: 80.6%, 83.0%, 65.6% and 36.3% in the D614G, Alpha, Delta and Omicron group respectively. The differences between the D614G, Alpha and Delta groups were not statistically significant. The Omicron group demonstrated a significantly lower prevalence of OD than the other variants but still significantly higher than the controls. Conclusions: During the Omicron wave OD was less prevalent than during the D614G, Alpha and Delta periods. One-third of patients have reduced olfactory function on psychophysical evaluation during the Omicron wave. Our results should be considered with caution as the VOC has not been determined with certainty.

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The study of olfactory dysfunction in SARS-CoV-2 variants

Cited by 2 publications

References 15 publications

Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Prevalence of olfactory dysfunction in D614G, alpha, delta and omicron waves: a psychophysical case-control study

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