2022
DOI: 10.3390/ijms23062940
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The Study of Protein–Cyclitol Interactions

Abstract: Investigation of interactions between the target protein molecule and ligand allows for an understanding of the nature of the molecular recognition, functions, and biological activity of protein–ligand complexation. In the present work, non-specific interactions between a model protein (Bovine Serum Albumin) and four cyclitols were investigated. D-sorbitol and adonitol represent the group of linear-structure cyclitols, while shikimic acid and D-(–)-quinic acid have cyclic-structure molecules. Various analytica… Show more

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Cited by 12 publications
(8 citation statements)
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“…Complementing the data delivered using independent measurement methods with the detailed thermodynamic information provided through the ITC test, the following considerations help in a more detailed characterization of the investigated interaction. A combination of numerous forces may be involved in the interaction between the proteins and their ligands, namely the hydrogen bonds, electrostatic, hydrophobic, and van der Waals forces [45,46]. The sign and magnitude of the Gibbs free energy, enthalpy, and entropy changes of the binding process can be correlated with the types of interactions that may occur in protein association processes [47].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Complementing the data delivered using independent measurement methods with the detailed thermodynamic information provided through the ITC test, the following considerations help in a more detailed characterization of the investigated interaction. A combination of numerous forces may be involved in the interaction between the proteins and their ligands, namely the hydrogen bonds, electrostatic, hydrophobic, and van der Waals forces [45,46]. The sign and magnitude of the Gibbs free energy, enthalpy, and entropy changes of the binding process can be correlated with the types of interactions that may occur in protein association processes [47].…”
Section: Discussionmentioning
confidence: 99%
“…Based on the outcomes of the independent techniques (listed in Table S4), the interaction of TIA-AuNCS with the protein is a spontaneous process (ΔG < 0), and based on the ITC results, the entropic and enthalpic terms show that the binding complex formation is an exothermic process, while the reaction is enthalpically driven at the Complementing the data delivered using independent measurement methods with the detailed thermodynamic information provided through the ITC test, the following considerations help in a more detailed characterization of the investigated interaction. A combination of numerous forces may be involved in the interaction between the proteins and their ligands, namely the hydrogen bonds, electrostatic, hydrophobic, and van der Waals forces [45,46]. The sign and magnitude of the Gibbs free energy, enthalpy, and entropy changes of the binding process can be correlated with the types of interactions that may occur in protein association processes [47].…”
Section: Discussionmentioning
confidence: 99%
“…5 Given the diversified spatial disposition of multiple hydroxyl groups on the carbocyclic backbone in cyclitols, generation of distinctive supramolecular motifs through various hydrogen bonding interactions in the solid state is inherent to these constructs and has been also receiving much attention. 6…”
Section: Introductionmentioning
confidence: 99%
“…Shikimic acid (SA) is a natural organic compound and an important intermediate in the biosynthesis of aromatic compounds in plants [31]. Studies have shown that SA has many biological activities, including antibacterial, anti-inflammatory, and antioxidant activities [32,33]. SA has been shown to be available in terms of action against S. aureus [34], and the effect of SA on the cellular functions of MRSA was investigated by measuring the intracellular pH, ATP concentration, and DNA content.…”
Section: Introductionmentioning
confidence: 99%