The study of radiosensitivity in left handed compared to right handed healthy women

Abstract

BackgroundRadiosensitivity is an inheriting trait that mainly depends on genetic factors. it is well known in similar dose of ionizing radiation and identical biological characteristics 9–10 percent of normal population have higher radiation response. Some reports indicate that distribution of breast cancer, immune diseases including autoimmune diseases as example lupus, Myasthenia Gravies and even the rate of allergy are more frequent in left handed individuals compared to right handed individuals. The main goal of the present study is determination of radiosensitivity in left handed compared to right handed in healthy women by cytokinesis blocked micronuclei [CBMN] assay.5 ml peripheral fresh blood sample was taken from 100 healthy women including 60 right handed and 40 left handed. The age of participants was between 20–25 old years and they had been matched by sex. After blood sampling, blood samples were divided to 2 groups including irradiated and non-irradiated lymphocytes that irradiated lymphocytes were exposed to 2 Gy CO-60 Gama rays source then chromosomal aberrations was analyzed by CBMN [Cytokinesis Blocked Micronuclei Assay].ResultsOur results have shown radiosensitivity index [RI] in left-handers compared to right-handers is higher. Furthermore, the mean MN frequency is elevated in irradiated lymphocytes of left-handers in comparison with right-handers.ConclusionOur results from CBMN assay have shown radiosensitivity in the left handed is higher than right handed women but more attempts need to prove this hypothesis.

Assessment of Individual Radiosensitivity in Inhabitants of Takandeang Village － A High Background Radiation Area in Indonesia

“…Since in our study all samples have Rh+, we cannot evaluate the association between Rh and radiosensitivity. Another study by Khosravifarsani et al in 2012 showed that radiosensitivity of lefthanders is higher compared to right-handers in healthy female samples [32]. Unfortunately, in this study, we did not evaluate whether the samples are left or right handers.…”

Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon

“…Fritschi et al have stated that workers dealing with pesticides such as Diazinon are at risk of lymphoma cancer especially non-Hodgkin [5]. The effects of radiation on CBMN assay scores were also proved by many studies [6].…”

“…The CBMN assay is a standard technique for evaluation of chemical materials and ionizing radiation effects on the DNA. In-vitro CBMN assay was used for measuring the differences in radiosensitivity and DNA damage in different studies [20][21][22]. In this assay, DNA damage could be scored by different indices, including micronuclei, nucleoplasmic bridges, and nuclear buds within binucleated cells [23].…”

“…There are still unknown factors which can cause malignant lymphoma, but there are a lot of risk factors such as immune deficiency, some specific infections and occupational exposures [5]. There are a lot of studies in the field of carcinogenesis of chemicals and pesticides [6].…”