The study of some possible measurement errors in clinical blood electrolyte potentiometric (ISE) analysers

Are your hands clean enough for point-of-care electrolyte analysis?

“…Previous studies have identified several potential causes of interference of electrolyte analysis with ISE-based instruments. [6][7][8][9][10] These problems include contamination of samples, 6 difference in electrode design, 6,[8][9][10] variations in salt bridge solution, 6,8,10 and interfering substances in the blood specimen itself. 6,8,9 To the best of our knowledge, the interference effects of hand disinfectants on electrolyte measurements by ISEbased analysers have not been previously reported.…”

Rapid and Precise Coulometric Determination and Separation of Redox Inert Ions Based on Electrolysis for Ion Transfer at the Aqueous|Organic Solution Interface

“…However, it is not easy to obtain meaningful results based on the potential at the ISE which is linear to the logarithm of the concentration of the ion, since the variation of the concentration of Ca 2+ , cCa 2+ , in the sample is small. For example, the range of the normal concentration of Ca in a blood serum sample is reported to be between 2.12 and 2.55 × 10 -3 M. [28][29][30] The coulometry by using the FECRIT system is expected to be useful for the precise electrochemical determination of Ca 2+ . It overcomes the difficulty of the ISE, since Il or Q observed by the FECRIT is proportional to cCa 2+ , and it is available for the absolute determination without using a calibration curve.…”

Development of Suitable ISE Measurement Procedures for SI-Traceable Chemical Activity Determination

“…[2] The uncertainty in E J is generally considered as a major source of bias in ISE measurements, whereas the uncertainty of the dynamic term is usually not considered. [30,31] …”