The study of the changes in the biochemical and mineral contents of bones of <i>Catla catla</i> due to lead intoxication

Palaniappan, P. L. R. M.; Krishnakumar, N.; Vadivelu, Murali K.; Vijayasundaram, V.

doi:10.1002/tox.20475

Cited by 10 publications

(1 citation statement)

References 29 publications

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“…Exposure to lead (Pb) also decreased bone crystallinity, and Ca, Mg, and P contents. This seems to be due to the high efficiency of bones to store lead by the ability of Ca hydroxyapatite to exchange cations (Suzuki et al, 1981) and by the low solubility of lead-to-lead phosphates in Pb-hydroxyapatite (Palaniappan et al, 2010). In fact, the quantification of Pb content in opercular bone has been proposed as a suitable monitoring procedure for Pb environmental exposure (Hodson et al, 1978).…”

Section: Osteotoxicants Mimicking Natural Compoundsmentioning

confidence: 99%

Fish as a model to assess chemical toxicity in bone

et al. 2018

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Environmental toxicology has been expanding as growing concerns on the impact of produced and released chemical compounds over the environment and human health are being demonstrated. Among the toxic effects observed in organisms exposed to pollutants, those affecting skeletal tissues (osteotoxicity) have been somehow overlooked in comparison to hepato-, immune-, neuro- and/or reproductive toxicities. Nevertheless, sub-lethal effects of toxicants on skeletal development and/or bone maintenance may result in impaired growth, reduced survival rate, increased disease susceptibility and diminished welfare. Osteotoxicity may occur by acute or chronic exposure to different environmental insults. Because of biologically and technically advantagous features - easy to breed and inexpensive to maintain, external and rapid rate of development, translucent larvae and the availability of molecular and genetic tools - the zebrafish (Danio rerio) has emerged in the last decade as a vertebrate model system of choice to evaluate osteotoxicity. Different experimental approaches in fish species and analytical tools have been applied, from in vitro to in vivo systems, from specific to high throughput methodologies. Current knowledge on osteotoxicity and underlying mechanisms gained using fish, with a special emphasis on zebrafish systems, is reviewed here. Osteotoxicants have been classified into four categories according to the pathway involved in the transduction of the osteotoxic effects: activation/inhibition of membrane and/or nuclear receptors, alteration of redox condition, mimicking of bone constituents and unknown pathways. Knowledge on these pathways is also reported here as it may provide critical insights into the development, production and release of future chemical compounds with none or low osteotoxicity, thus promoting the green/environmental friendly chemistry.

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Section: Osteotoxicants Mimicking Natural Compoundsmentioning

confidence: 99%

Fish as a model to assess chemical toxicity in bone

et al. 2018

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Osteosclerotic metaphyseal dysplasia with extensive interstitial pulmonary lesions: a case report and literature review

et al. 2015

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Osteosclerotic metaphyseal dysplasia (OMD) is a very rare sclerosing bone disorder. To date, four cases have been documented in three reports. Here, we present the case of a 12-year-old girl with a history of recurrent respiratory infections, hypotonia, developmental delay, genu valgum, and hepatosplenomegaly. Radiographs revealed profound, ivory-white sclerosis of the metaphyses and epiphyses of the long bones in both the upper and lower extremities. Sclerosis also affected the ends or margins of the flat bones, including the mandible, clavicles, scapulae, ribs, iliac crests, ischia, pubic bones, talus, calcaneus, and some vertebrae, to varying degrees. Based on the clinical, radiographic, and laboratory findings, a diagnosis of OMD was made. Our patient is the fifth case of OMD reported in the international literature and shares clinical and radiological similarities with four other reported cases of OMD. However, the extensive interstitial pulmonary lesions observed on computed tomography images in the present case have not been previously documented. This pulmonary disorder, which may be associated with OMD, should be evaluated in subsequently encountered cases.

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Experimental investigation of the effect of crosslinking fibers on mechanical properties of deer’s antlers

Tuncer

Orhan²

2022

Sādhanā

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The study of the changes in the biochemical and mineral contents of bones of Catla catla due to lead intoxication

Cited by 10 publications

References 29 publications

Fish as a model to assess chemical toxicity in bone

Fish as a model to assess chemical toxicity in bone

Osteosclerotic metaphyseal dysplasia with extensive interstitial pulmonary lesions: a case report and literature review

Experimental investigation of the effect of crosslinking fibers on mechanical properties of deer’s antlers

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