The sub-cellular fate of mercury in the liver of wild mullets (Liza aurata) – Contribution to the understanding of metal-induced cellular toxicity

Araújo, Olinda; Pereira, Patrícia; Cesário, Rute; Pacheco, Mário; Raimundo, Joana

doi:10.1016/j.marpolbul.2015.03.036

Cited by 9 publications

(3 citation statements)

References 47 publications

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“…In the Ria de Aveiro, metal(loid) bioaccumulation has been investigated in many taxa above bivalves, such as foraminifera (Martins et al, 2010;), polychaetes (Freitas et al, 2012bPires et al, 2017), gastropods (Cardoso et al, 2013) and crustaceans (D'Ambrosio et al, 2013); among vertebrates, several fish species and their parasites have been studied (as examples Cid et al, 2001;Eira et al, 2009;Araujo et al, 2015). No data are currently available for bird species.…”

Section: Manila Clam Management Strategies In the Ria De Aveiro Lagoonmentioning

confidence: 99%

Biogeochemical dynamics and bioaccumulation processes in Manila clam: Implications for biodiversity and ecosystem services in the Ria de Aveiro Lagoon

Breda

Chiesa

Freitas

et al. 2018

Estuarine, Coastal and Shelf Science

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The present work was carried out in the Ria de Aveiro Lagoon (Portugal) to better understand the dynamics driving the bioaccumulation processes in edible bivalves, namely in the Manila clam Ruditapes philippinarum. For the first time, a holistic approach was applied, collecting data on sediment physico-chemical characteristics and its contamination, geochemical speciation and metal(loid) bioaccumulation in clams, from three exploited areas of the lagoon (Costa Nova, Torreira, Ílhavo). The Ria de Aveiro Lagoon is part of the Natura 2000 network, has the designation of Special Protection Area (SPA), contains Sites of Community Importance (SCI), it is protected by the EU Birds Directive (79/109/CEE) and includes a natural reserve in its northern part. Specifically concerning the metal(loid) occurrence, the monitoring and the identification of contaminated sites in protected areas are priorities, to improve the biodiversity conservation efforts and to ensure the correct management of natural resources. Results showed that multiple driving forces interacted together to determine site-specific impacts, resulting in different risks at local scale for the transferring of the metal(loid)s to the trophic chain. Hydrodynamics played a major role driving the occurrence of depositional or ablative sites, influencing the granulometric composition of sediments and their contamination; metal(loid) chemical forms were then determinated by multiple factors like pH, redox potential and organic matter content. The geochemical speciation data showed that the Ílhavo area should be considered the most dangerous in terms of clam consumption, since in case of environmental changes, possible conversion of the elements from the potentially bioavailable forms to the bioavailable ones can occur. Moreover, bioaccumulation processes in Manila clam were observed for Cd, Zn and especially As, the latter representing serious risk for consumer safety throughout clam consumption.

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Section: Manila Clam Management Strategies In the Ria De Aveiro Lagoonmentioning

confidence: 99%

Biogeochemical dynamics and bioaccumulation processes in Manila clam: Implications for biodiversity and ecosystem services in the Ria de Aveiro Lagoon

Breda

Chiesa

Freitas

et al. 2018

Estuarine, Coastal and Shelf Science

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“…In addition to MeHg demethylation within whole tissues, other biochemical processes, such as intracellular binding of Hg, may play an important role in influencing Hg toxicokinetics and risk in birds. Recent studies have used subcellular partitioning procedures to determine how metals are distributed among subcellular fractions isolated from the tissues of aquatic organisms . These procedures, which often make use of differential centrifugation, allow for the distinction between metal‐binding to potentially sensitive target molecules (enzymes and organelles) and metal accumulation in detoxified fractions such as metal‐rich granules and heat‐stable proteins, including cysteine‐rich metallothionein and metallothionein‐like proteins .…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have focused on the subcellular distribution of Hg in fish liver , other fish tissues , invertebrates , and marine mammal liver . However, only one species of bird, a marine foraging, piscivorous species (black‐footed albatross, Diomedea nigripes , n = 5), has been investigated for subcellular distribution of Hg .…”

Section: Introductionmentioning

confidence: 99%

Mercury speciation and subcellular distribution in experimentally dosed and wild birds

Perkins

Barst

Hadrava

et al. 2017

Enviro Toxic and Chemistry

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Many bird species are exposed to methylmercury (MeHg) at levels shown to cause sublethal effects. Although MeHg sensitivity and assimilation can vary among species and developmental stages, the underlying reasons (such as MeHg toxicokinetics) are poorly understood. We investigated Hg distribution at the tissue and cellular levels in birds by examining Hg speciation in blood, brain, and liver and Hg subcellular distribution in liver. We used MeHg egg injection of white leghorn chicken (Gallus gallus domesticus), sampled at 3 early developmental stages, and embryonic ring-billed gulls (Larus delawarensis) exposed to maternally deposited MeHg. The percentage of MeHg (relative to total Hg [THg]) in blood, brain, and liver ranged from 94 to 121%, indicating little MeHg demethylation. A liver subcellular partitioning procedure was used to determine how THg was distributed between potentially sensitive and detoxified compartments. The distributions of THg among subcellular fractions were similar among chicken time points, and between embryonic chicken and ring-billed gulls. A greater proportion of THg was associated with metal-sensitive fractions than detoxified fractions. Within the sensitive compartment, THg was found predominately in heat-denatured proteins (∼42-46%), followed by mitochondria (∼15-18%). A low rate of MeHg demethylation and high proportion of THg in metal-sensitive subcellular fractions further indicates that embryonic and hatchling time points are Hg-sensitive developmental stages, although further work is needed across a range of additional species and life stages. Environ Toxicol Chem 2017;36:3289-3298. © 2017 SETAC.

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Organotropism of total mercury (THg) in Cichla pinima, ecological aspects and human consumption in fish from Amazon region, Brazil

Azevedo

Hortellani

Sarkis

2019

Environ Sci Pollut Res

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The sub-cellular fate of mercury in the liver of wild mullets (Liza aurata) – Contribution to the understanding of metal-induced cellular toxicity

Cited by 9 publications

References 47 publications

Biogeochemical dynamics and bioaccumulation processes in Manila clam: Implications for biodiversity and ecosystem services in the Ria de Aveiro Lagoon

Biogeochemical dynamics and bioaccumulation processes in Manila clam: Implications for biodiversity and ecosystem services in the Ria de Aveiro Lagoon

Mercury speciation and subcellular distribution in experimentally dosed and wild birds

Organotropism of total mercury (THg) in Cichla pinima, ecological aspects and human consumption in fish from Amazon region, Brazil

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