The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance

Fei, Fei; Qu, Jie; Li, Kai; Li, Chunyuan; Wang, Xinlu; Li, Yuwei; Zhang, Shiwu

doi:10.1038/s41374-018-0157-x

Cited by 49 publications

(53 citation statements)

References 53 publications

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“…Owing to its function, it is found that CCNB1 is generally abnormal in tumors. CCNB1 was associated with pathologic grade and metastasis of tumors in cases of human breast and ovarian cancer (Fei et al, ). Several literatures found that the expression of CCNB1 was significantly associated with pathologic grade, metastasis, and prognosis of tumors (Ding et al, ; Zuryn, Krajewski, Klimaszewska‐Wisniewska, Grzanka, & Grzanka, ).…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis

Chen¹,

Wang

Shen

et al. 2019

Molec Gen & Gen Med

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Background Colorectal cancer (CRC) is one of the most common malignant tumors. In the present study, the expression profile of human multistage colorectal mucosa tissues, including healthy, adenoma, and adenocarcinoma samples was downloaded to identify critical genes and potential drugs in CRC. Methods Expression profiles, GSE33113 and GSE44076, were integrated using bioinformatics methods. Differentially expressed genes (DEGs) were analyzed by R language. Functional enrichment analyses of the DEGs were performed using the Database for Annotation, visualization, and integrated discovery (DAVID) database. Then, the search tool for the retrieval of interacting genes (STRING) database and Cytoscape were used to construct a protein–protein interaction (PPI) network and identify hub genes. Subsequently, survival analysis was performed among the key genes using Gene Expression Profiling Interactive Analysis (GEPIA). Connectivity Map (CMap) was used to query potential drugs for CRC. Results A total of 428 upregulated genes and 751 downregulated genes in CRC were identified. The functional changes of these DEGs were mainly associated with cell cycle, oocyte meiosis, DNA replication, p53 signaling pathway, and progesterone‐mediated oocyte maturation. A PPI network was identified by STRING with 482 nodes and 2,368 edges. Survival analysis revealed that high mRNA expression of AURKA, CCNB1, CCNF, and EXO1 was significantly associated with longer overall survival. Moreover, CMap predicted a panel of small molecules as possible adjuvant drugs to treat CRC. Conclusion Our study found key dysregulated genes involved in CRC and potential drugs to combat it, which may provide novel insights and potential biomarkers for prognosis, as well as providing new CRC treatments.

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Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis

Chen¹,

Wang

Shen

et al. 2019

Molec Gen & Gen Med

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“…There is a small body of literature specifically related to PGCCs (74 PubMed‐listed entries with query: [PGCCs] vs 3,857,567 with query [cancer]; accessed 10 May 2019; Figure ), but this literature, taken holistically, makes a compelling case for defining them as the essential keystone cancer species and actuators of tumorigenesis, therapeutic resistance, and recurrence in metastatic disease. Keystone species are relatively few in number, but have a significant impact on the health and composition of the ecosystem.…”

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confidence: 99%

“…This stem‐like phenotype of asymmetric division gives PGCCs the capacity to generate a clinically evident metastasis of majority non‐PGCC cells. In addition, there are recent data that PGCCs that form in response to hypoxia, such as would be found in the primary tumor microenvironment, and in response to therapy have increased metastatic potential, including increased mesenchymal phenotype as well as enhanced migration and invasion …”

mentioning

confidence: 99%

“…In addition, there are recent data that PGCCs that form in response to hypoxia, such as would be found in the primary tumor microenvironment, and in response to therapy have increased metastatic potential, including increased mesenchymal phenotype as well as enhanced migration and invasion. 42,97,127 As the field of PGCC research grows, it is important to set a definition of the cell type of interest. Pathologists have borrowed Theoretically, researchers may be able to take advantage of the relative size difference of PGCCs compared to the other cancer cells in the population using size-exclusion techniques such as have been developed for circulating tumor cell research, but such a method has not been widely adopted.…”

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confidence: 99%

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Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance

et al. 2019

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Cancer led to the deaths of more than 9 million people worldwide in 2018, and most of these deaths were due to metastatic tumor burden. While in most cases, we still do not know why cancer is lethal, we know that a total tumor burden of 1 kg—equivalent to one trillion cells—is not compatible with life. While localized disease is curable through surgical removal or radiation, once cancer has spread, it is largely incurable. The inability to cure metastatic cancer lies, at least in part, to the fact that cancer is resistant to all known compounds and anticancer drugs. The source of this resistance remains undefined. In fact, the vast majority of metastatic cancers are resistant to all currently available anticancer therapies, including chemotherapy, hormone therapy, immunotherapy, and systemic radiation. Thus, despite decades—even centuries—of research, metastatic cancer remains lethal and incurable. We present historical and contemporary evidence that the key actuators of this process—of tumorigenesis, metastasis, and therapy resistance—are polyploid giant cancer cells.

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“…PGCCs may undergo the process of budding and bursting in order to give birth to the daughter cells. The eukaryotic diploid cells in contrast undergo conventional growth pattern in mitosis which shows a visible distinction [31]. Giant cells can be subjected to reciprocation process with the help of depletion in the division, which leads to the reformation into the cancer cells having definite pattern.…”

Section: Polyploid Giant Cancer Cells (Pgccs)mentioning

confidence: 99%

Role of cancer stem cells in the development of giant cell tumor of bone

et al. 2020

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The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and is usually associated with the end point of a long bone. Giant cell tumor (GCT) involves mononuclear stromal cells which proliferate at a high rate, multinucleated giant cells and stromal cells are equally present in this type of tumor. Cancer stem cells (CSCs) have been confirmed to play a potential role in the development of GCT. Cancer stem cell-based microRNAs have been shown to contribute to a greater extent in giant cell tumor of bone. CSCs and microRNAs present in the tumors specifically are a great concern today which need indepth knowledge as well as advanced techniques to treat the bone cancer effectively. In this review, we attempted to summarize the role played by cancer stem cells involving certain important molecules/factors such as; Mesenchymal Stem Cells (MSCs), miRNAs and signaling mechanism such as; mTOR/PI3K-AKT, towards the formation of giant cell tumor of bone, in order to get an insight regarding various effective strategies and research advancements to obtain adequate knowledge related to CSCs which may help to focus on highly effective treatment procedures for bone tumors.

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The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance

Cited by 49 publications

References 53 publications

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis

Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance

Role of cancer stem cells in the development of giant cell tumor of bone

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