The subchronic oral toxicity of the ?-isomer of hexachlorocyclohexane in rats

Velsen, F.L. van; Danse, L. H. J. C.; Leeuwen, F.X.R. van; Dormans, J. A. M. A.; Logten, M.J. van

doi:10.1016/0272-0590(86)90183-1

Cited by 44 publications

(16 citation statements)

References 21 publications

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“…In contrast, in utero or post-natal HCB and β-HCH exposure caused reproductive and developmental abnormalities but did not affect the timing of PPS (Arnold et al, 1985; Courtney 1979; Simon et al, 1979; Van Velsen et al, 1986). Epidemiologic evidence on the associations of OCPs and puberty is sparse and inconsistent.…”

Section: Introductionmentioning

confidence: 72%

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Lam

Williams

Lee

et al. 2014

Environment International

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Background In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development, however, epidemiological data are limited and inconsistent. Objective To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocylohexane (β-HCH), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE)] with male pubertal onset. Methods In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8–9 year old boys with measured OCPs were enrolled during 2003–2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV) > 3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. Results In adjusted models, boys with higher HCB concentrations had later mean ages of TV > 3 mL and P2+ (but not G2+). Mean age at attaining TV > 3 mL was delayed 3.6 (95% CI: −2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: −1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: −5.8, 5.6) for Q2, 4.7 months later (95% CI: −1.0, 10.3) for Q3 and 4.6 months later (95% CI: −1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p′-DDE concentrations with age of pubertal onset. Conclusion Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.

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Section: Introductionmentioning

confidence: 72%

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Lam

Williams

Lee

et al. 2014

Environment International

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“…(AMAP 1998(AMAP , 2004Colborn and Clement 1992;Colborn, Saal, and Soto1993;Colborn 2004;Kupfer and Bulger 1980). Hexachlorobenzene (HCB) and b-hexachlorocyclohexane (b-HCH) are anti-androgenic and anti-estrogenic, respectively (Elissalde and Clark 1979;Van Velsen et al 1986). Competitivebinding studies using estrogen receptors from humans demonstrated that CB ¡104, ¡184, and ¡188 all were significant competitors, and thus possess estrogen-like activity (Matthews and Zacharewski 2000).…”

Section: Introductionmentioning

confidence: 98%

Steroid hormones in blood plasma from Greenland sledge dogs (Canis familiaris) dietary exposed to organohalogen polluted minke whale (Balaenoptera acuterostrata) blubber

Sonne¹,

Dietz²,

Letcher³

et al. 2014

Toxicological & Environmental Chemistry

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“…Lindane was reported to have both estrogenic and antiestrogenic effects in female rats (226). In male weanling rats fed with ,B-HCH (0, 2, 10, 50, or 250 mg/kg) for 13 weeks, liver enzyme induction occurred at doses > 2 mg/kg; testis weights decreased at doses > 50 mg/kg; and testicular atrophy resulted from a dose of 250 mg/kg (227).…”

Section: Organochlorine Pesticidesmentioning

confidence: 99%

Male Reproductive Health and Environmental Xenoestrogens

Toppari¹,

Larsen²,

Christiansen³

et al. 1996

Environmental Health Perspectives

361

340

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Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time. Incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention. Environ Health Perspect 104(Suppl 4): 741-803 (1996)

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The subchronic oral toxicity of the ?-isomer of hexachlorocyclohexane in rats

Cited by 44 publications

References 21 publications

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Steroid hormones in blood plasma from Greenland sledge dogs (Canis familiaris) dietary exposed to organohalogen polluted minke whale (Balaenoptera acuterostrata) blubber

Male Reproductive Health and Environmental Xenoestrogens

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