The subsequent biological effects of simulated microgravity on endothelial cell growth in HUVECs

Xu, Dan; Guo, Yubing; Zhang, Min; Sun, Yeqing

doi:10.1016/j.cjtee.2018.04.004

Cited by 12 publications

(16 citation statements)

References 36 publications

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“…Both micro-and hyper-gravity was shown to affect various cellular processes such as gene expression [304,305], proliferation [306], differentiation [307][308][309][310][311][312], autophagy [310,313,314] and cell death [305,310,315]. Although the mechanism of cellular graviperception remains unclear [316,317], previous studies suggested an essential role of the cytoskeleton [305], adhesive molecules [318], and cell membrane mechanoreceptors in that process. It is known that the reorganization of cytoskeletal fibers caused by mechanical forces such as altered gravity strongly alters cell functioning [294,319,320].…”

Section: Gravitational Forces Affecting Biomembranesmentioning

confidence: 99%

Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy

et al. 2021

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Modifications of the composition or organization of the cancer cell membrane seem to be a promising targeted therapy. This approach can significantly enhance drug uptake or intensify the response of cancer cells to chemotherapeutics. There are several methods enabling lipid bilayer modifications, e.g., pharmacological, physical, and mechanical. It is crucial to keep in mind the significance of drug resistance phenomenon, ion channel and specific receptor impact, and lipid bilayer organization in planning the cell membrane-targeted treatment. In this review, strategies based on cell membrane modulation or reorganization are presented as an alternative tool for future therapeutic protocols.

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Section: Gravitational Forces Affecting Biomembranesmentioning

confidence: 99%

Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy

et al. 2021

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“…Recent studies also suggested that autophagy and mitophagy play a protective role against ER stress-mediated apoptosis in simulated-microgravity-exposed HUVECs [ 99 , 100 ]. However, Xu et al [ 101 ] reported that HUVECs showed increased apoptosis after the return to normal gravity. A possible explanation could be the expression of transcription factors, such as serum response factor (SRF) and mammalian target of rapamycin (mTOR), which are critical regulators in vascular ECs and are associated with endothelial dysfunction.…”

Section: Impact Of Microgravity On Apoptosis In Different Cell Typmentioning

confidence: 99%

“…A possible explanation could be the expression of transcription factors, such as serum response factor (SRF) and mammalian target of rapamycin (mTOR), which are critical regulators in vascular ECs and are associated with endothelial dysfunction. Both factors were altered during simulated microgravity exposure [ 101 ].…”

Section: Impact Of Microgravity On Apoptosis In Different Cell Typmentioning

confidence: 99%

Influence of Microgravity on Apoptosis in Cells, Tissues, and Other Systems In Vivo and In Vitro

Prasad

Grimm

Strauch

et al. 2020

IJMS

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All life forms have evolved under the constant force of gravity on Earth and developed ways to counterbalance acceleration load. In space, shear forces, buoyance-driven convection, and hydrostatic pressure are nullified or strongly reduced. When subjected to microgravity in space, the equilibrium between cell architecture and the external force is disturbed, resulting in changes at the cellular and sub-cellular levels (e.g., cytoskeleton, signal transduction, membrane permeability, etc.). Cosmic radiation also poses great health risks to astronauts because it has high linear energy transfer values that evoke complex DNA and other cellular damage. Space environmental conditions have been shown to influence apoptosis in various cell types. Apoptosis has important functions in morphogenesis, organ development, and wound healing. This review provides an overview of microgravity research platforms and apoptosis. The sections summarize the current knowledge of the impact of microgravity and cosmic radiation on cells with respect to apoptosis. Apoptosis-related microgravity experiments conducted with different mammalian model systems are presented. Recent findings in cells of the immune system, cardiovascular system, brain, eyes, cartilage, bone, gastrointestinal tract, liver, and pancreas, as well as cancer cells investigated under real and simulated microgravity conditions, are discussed. This comprehensive review indicates the potential of the space environment in biomedical research.

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“…The application of an appropriate exogenous MT concentration can promote the growth of young rice buds under nickel (Ni) stress and alleviate the toxicity of Ni to rice seedlings [3]. Under high-temperature stress, MT inhibits reactive oxygen species (ROS) production in cucumber seedlings, improves antioxidant enzyme activities, inhibits the reduction of chlorophyll a, and increases the chlorophyll a/b ratio and carotenoid content, which reduces the damage caused by high-temperature stress on cucumber seedlings and maintains the photosynthetic rate at a relatively high level [4][5]. MT can also enhance the resistance of tomato to cadmium (Cd) by improving antioxidant enzyme activities and promoting the integration and isolation of Cd in plants [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Melatonin-Soaked Seeds on the Cadmium Accumulation in Broadbean (Vicia faba) Seedlings

Jian¹,

Chen²,

Lin³

2018

Proceedings of the 2018 7th International Conference on Energy, Environment and Sustainable Development (ICEESD 2018)

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In order to discuss the melatonin (MT) on the growth and cadmium (Cd) accumulation in vegetables, broadbean (Vicia faba) seeds were soaked in five doses (0, 50, 100, 150 and 200 µmol/L) of MT and then planted in pots containing Cd-contaminated soil. Different doses of MT increased the biomasses of broadbean seedlings' roots and shoots compared with the control, with 200 µmol/L of MT producing the maximum values. MT effectively decreased the Cd contents in roots and shoots of broadbean seedlings compared with the control, and the maximum reduction rate of 29.29% occurred at the 200-µmol/L MT dose. Thus, MT could promote broadbean growth and reduce Cd accumulation in broadbean, with 200 µmol/L being the optimum dose in this experiment. Materials and Methods Materials. Local varieties of broadbean grown in Chengdu, Sichuan Province, China were used in this study. The soil samples were fluvo-aquic soils, which were collected from the Chengdu Campus Farm of Sichuan Agricultural University (30°42′ N, 103°51′ E) in October 2015. The soil basic properties and its Cd content were described in Liu et al. (2015) [7]. Then, 0.5 kg of air-dried soil was placed into each polyethylene pot (10-cm high, 8-cm diameter). Cd (CdCl 2 •2.5 H 2 O) was added to the soil samples at a dose of 10 mg/kg according to [8]. The soil moisture was maintained at 80% of field capacity for one month. Experimental Design. In November 2015, the seeds of broadbean were soaked in different doses (0, 50, 100, 150 and 200 µmol/L) of MT for 48 h. A 50-mL solution soaked approximately 15 seeds.

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The subsequent biological effects of simulated microgravity on endothelial cell growth in HUVECs

Cited by 12 publications

References 36 publications

Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy

Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy

Influence of Microgravity on Apoptosis in Cells, Tissues, and Other Systems In Vivo and In Vitro

Effects of Melatonin-Soaked Seeds on the Cadmium Accumulation in Broadbean (Vicia faba) Seedlings

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