Background: Ultrasound-guided internal jugular vein (IJV) cannulation is known for increasing success rate and decreasing rate of complications. Aims: The aim of the study is to compared ultrasonography guided techniques namely ultrasound guided real time imaging for right IJV catheter insertion, ultrasound guided prelocation of right IJV catheterization with the classical anatomical landmark technique for right IJV cannulation in terms of success rate, time for cannulation and complications. Settings and Design: A prospective, randomized, observational study was conducted at a tertiy care hospital. Methods: One hundred twenty patients 40 in each group requiring IJV cannulation were included in this study and were randomly allocated in three groups. Number of attempts, success rate, venous access time, IJVcatheterization time, and complications were observed in each group. Statistical Analysis Used: All data were analysed by proper statistical test using SPSS-21, with the consultation of institutional statistician. Parametric values were taken as mean (SD), and nonparametric values were taken as median (range). For the inter-group comparison of parametric tests, their distributions were established and Student's t-test was implemented. Mann-Whitney U test was applied in nonparametric measurements. For all tests, p (probability) value of <0.05 was considered significant and p < 0.001 was considered as highly Significant. Results: Single attempt catheterization seen in 70% in Group A, 90% in Group B & 87.50% in Group C and it is significant. Failure is seen in 5% cases in Group A only. The time required for venous access was ranging a from 5 seconds to 110 seconds with mean time 24.25 sec in group A, ranging from 5 seconds to 30 seconds with mean time 16.12 sec in group B, time required for venous access was ranging from 5 seconds to 90 seconds with mean time 20.5 sec in group C study population. The result is significant (p-value 0.012). The time required for catheterization was ranging from 150 sec to 1500 sec with mean time 583.12 sec in group A, ranging from 200 sec to 900 sec with mean time 403.75 sec in group B, time required for catheterization was ranging from 200 sec to 1500 sec with mean time 410.0 sec in group C study population. However the result is not significant (p-value 0.123). Carotid artery puncture is seen in 22.5 %( group A), 0% (group B), 12.5% (group C). Pneumotthorax 2.5 % is seen in group A only. Haematoma and catheter malposition is not seen in any group. Conclusion: We found that the Real-time ultrasonography guidance provides a faster access, lesser number of attempt, lesser complication.