The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet

Shimizu, Ryo; Ohwada, Chikako; Nagao, Yuhei; Togasaki, Emi; Kawajiri, Chika; Muto, Tomoya; Tsukamoto, Shokichi; Sakai, Shio; Takeda, Yusuke; Mimura, Naoya; Takeuchi, Masahiro; Sakaida, Emiko; Iseki, Tohru; Nakaseko, Chiaki

doi:10.2169/internalmedicine.56.6930

Cited by 8 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, blisters were also present on the face. Some reports have been published describing urinary retention in a case with herpes zoster facial blisters in a patient who also had meningitis [21][22][23]. Table 1 shows the characteristics of disseminated herpes zoster cases with a skin rash on the face.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Herpes Zoster Infection with Urinary Retention and Incontinence

Norimatsu¹,

Ohno²

2020

IJIDT

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Disseminated Herpes Zoster Infection with Urinary Retention and Incontinence

Norimatsu¹,

Ohno²

2020

IJIDT

View full text Add to dashboard Cite

“…VZV vasculopathy may also co-manifest in the central nervous system (CNS) as stroke, aneurysm, dissection, and other vascular abnormalities [3 ▪ ]. Several case reports have also demonstrated an association between VZV vasculopathy and prior, subsequent, and/or concurrent viral meningitis or encephalitis [5,6].…”

Section: Pathogenesis Of Varicella Zoster Virus Occlusive Retinal Vas...mentioning

confidence: 99%

Retinal vasculopathy following varicella zoster virus infection

Sutra

Pokawattana

2022

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

Purpose of reviewVaricella zoster virus (VZV) ocular infection can manifest purely as a vasculopathy that leads to retinal arteriole occlusion, without any retinitis or vasculitis. This review summarizes our current knowledge of such VZV ocular infection phenotype, incorporating initial descriptions from 1988. We describe the pathogenesis and VZV's manifestations in the retina using fundus photography, fundus fluorescein angiography, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Laboratory investigations, diagnostic procedures, prognoses, and treatment options are also being reviewed.Recent findingsTen case reports where VZV retinal vasculopathy was the primary feature observed after varicella or zoster rash are described. The retinal arteriole, cilioretinal artery, branches of retinal artery, central retinal artery and ophthalmic artery were found to be areas of more rarely affected, neither in the form of vasculitis nor retinitis. Diagnosis is typically made from positive polymerase chain reaction (PCR) for VZV from extracted intraocular fluid or positive serum or cerebrospinal fluid (CSF) anti-VZV immunoglobulin G antibody in the context of compatible ocular findings. In addition, retinal vasculopathy occurring in the setting of confirmed varicella or zoster rashes could be considered potentially pathognomonic. Pathological concepts, including direct VZV infection of affected tissue, persistent inflammation, and/or virus-induced hypercoagulability are also discussed.SummaryVZV may produce a wide spectrum of ocular manifestations with isolated VZV retinal vasculopathy being a rarer presentation. A prompt diagnosis followed by an early treatment of systemic acyclovir with or without corticosteroids is the mainstay of treatment.

show abstract

“…Early radical antiviral treatment of HZ could be helpful to prevent the progress of PHN. However, toxicity and side effects should be considered with long term and high dose of antiviral agents 10 . Thus, it is clinical urgency to seek potential biomarkers to predict PHN accurately for PHN management.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics profiling in predicting of post-herpetic neuralgia induced by varicella zoster

Lu,

Mei,

et al. 2023

Sci Rep

View full text Add to dashboard Cite

To explore potential metabolomics biomarkers in predicting post-herpetic neuralgia (PHN) induced by herpes zoster (HZ). A total of 90 eligible patients were prospectively enrolled and assigned into an acute pain (ACP) group and a PHN group. Serum samples were collected before clinical intervention to perform metabolomics profiling analyses using gas chromatography mass spectrometry (GC–MS). Key metabolites were identified using partial least squares discriminant analysis (PLS-DA). A binary logistic regression was used to build a combined biomarker model to predict PHN from ACP. The discriminating efficiency of the combined biomarker model was investigated and validated by internal validation. Six metabolites were identified as the key metabolites related to PHN. All these metabolites (N-Acetyl-5-hydroxytryptaMine, glucose, dehydroascorbic acid, isopropyl-beta-d-thiogalactopyranoside, 1,5-anhydro-d-sorbitol, and glutamic acid) were found elevated in the PHN group. Pathway analyses showed that glucose-alanine cycle, tryptophan metabolism, tyrosine metabolism, lactose degradation, malate-aspartate shuttle were top five metabolic pathways evolved in PHN. The AUC was 0.85 (95% CI 0.76–0.93) for the combined biomarker model, and was 0.91 (95% CI 0.84–1.00) for the internal validation data set to predict PHN. Metabolomics analyses of key metabolites could be used to predict PHN induced by HZ.

show abstract

The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet

Cited by 8 publications

References 26 publications

Disseminated Herpes Zoster Infection with Urinary Retention and Incontinence

Disseminated Herpes Zoster Infection with Urinary Retention and Incontinence

Retinal vasculopathy following varicella zoster virus infection

Metabolomics profiling in predicting of post-herpetic neuralgia induced by varicella zoster

Contact Info

Product

Resources

About