The Successful Use of Desmopressin With Tranexamic Acid in Children With Mild Type 1 Von Willebrand Disease Who Undergo Circumcision

Abstract

Background: Desmopressin (DDAVP) is a synthetic vasopressin analog, and increases endogenous von Willebrand factor (VWF) by secreting it from the vascular endothelial cell. Circumcision is one of the oldest and most commonly performed operations in the world. This study reported the specific uses of DDAVP together with tranexamic acid in children with mild type 1 von Willebrand disease (VWD) undergoing circumcision. The aim of this study was to report the successful use of DDAVP in two doses and tranexamic acid in six children with VWD undergoing circumcision.