The sugar phosphate/phosphate exchanger family <scp>SLC37</scp>

Olcese, Chiara; Bartoloni, Lucia

doi:10.1002/wmts.98

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…Mapping of the blb mutation identified an interval on chromosome 5 that includes Slc37a2, a solute carrier transporter (Figure 3A;STAR Methods;Chou and Mansfield, 2014;Chou et al, 2013;Pan et al, 2011;Olcese and Bartoloni, 2013). Both NY007 (blb t30301 ) and NI150 (blb t30913 ), two non-complementing blb alleles, have a point mutation in the slc37a2 locus that leads to a premature stop codon ( Figure 3A).…”

Section: The Solute Carrier Transporter Slc37a2 Localizes To Phagosommentioning

confidence: 99%

Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment

et al. 2019

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Graphical Abstract Highlights d Neuronal processing by microglia depends on Slc37a2mediated phagosomal shrinkage d Phagosomes fuse with the gastrosome, a unique compartment in the phagocytic pathway d Loss of Slc37a2 blocks phagosomal shrinkage, resulting in gastrosomal expansion d Gastrosomal expansion affects microglia phagocytosis and migration toward injuries SUMMARYPhagocytic immune cells such as microglia can engulf and process pathogens and dying cells with high efficiency while still maintaining their dynamic behavior and morphology. Effective intracellular processing of ingested cells is likely to be crucial for microglial function, but the underlying cellular mechanisms are poorly understood. Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell. This, in turn, affects the ability of microglia to phagocytose and migrate toward brain injuries. Thus, this work identifies a conserved crucial step in the phagocytic pathway of immune cells and provides a potential entry point for manipulating their behavior in development and disease.

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Section: The Solute Carrier Transporter Slc37a2 Localizes To Phagosommentioning

confidence: 99%

Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment

et al. 2019

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“…The SLC family is a member of the Major Facilitator Superfamily (MFS), which is mainly responsible for the transport of various carbohydrates, organic alcohols, and other substances in organisms [ 39 ]. Although more than 100 transporter families have been identified and classified, the SLC family is the second largest membrane protein family after G-protein-coupled receptors [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16

Ma,

He,

Liu

et al. 2024

Genes

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The excessive deposition of abdominal adipocytes in chickens is detrimental to poultry production. However, the regulatory factors that affect abdominal adipogenesis in chickens are still poorly understood. SLC22A16 is differentially expressed in abdominal preadipocytes and 10-day differentiated adipocytes in chickens, but its role in regulating chicken adipogenesis has not been reported. In this study, the function of SLC22A16 in chicken abdominal preadipocytes was investigated. SLC22A16 is significantly upregulated during abdominal adipocyte differentiation. The overexpression of SLC2A16 upregulated the expression of adipogenic marker genes and proliferation-related genes, and promoted the proliferation of adipocytes and the accumulation of triglycerides. The knockdown of SLC22A16 downregulated the expression of adipogenic marker genes and proliferation-related genes, inhibited the proliferation of adipocytes, and impaired the accumulation of triglycerides in adipocytes. In addition, LNC6302 was differentially expressed in abdominal preadipocytes and mature adipocytes, and was significantly positively correlated with the expression of SLC22A16. Interference with LNC6302 inhibits the expression of adipogenic marker genes and proliferation-related genes. The data supported the notion that LNC6302 promotes the differentiation of chicken abdominal adipocytes by cis-regulating the expression of SLC22A16. This study identified the role of SLC22A16 in the differentiation and proliferation of chicken adipocytes, providing a potential target for improving abdominal adipogenesis in chickens.

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The transcriptome of the marine calanoid copepod Temora longicornis under heat stress and recovery

Semmouri

Asselman

Nieuwerburgh

et al. 2019

Marine Environmental Research

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Understanding the impacts of global change in zooplankton communities is crucial, as alterations in the zooplankton communities can affect entire marine ecosystems. Despite the economic and ecological importance of the calanoid copepod Temora longicornis in the Belgian part of the North Sea, molecular data is still very limited for this species. Using HiSeq Illumina sequencing, we sequenced the whole transcriptome of T. longicornis, after being exposed to realistic temperatures of 14 and 17 °C. After both an acute (1 day) and a more sustained (5 days) thermal exposure to 17 °C, we investigated gene expression differences with animals exposed to 14 °C, which may be critical for the thermal acclimation and resilience of this copepod species. We also studied the possibility of a short term stress recovery of a heat shock. A total of 179,569 transcripts were yielded, of which 44,985 putative ORF transcripts were identified. These transcripts were subsequently annotated into roughly 22,000 genes based on known sequences using Gene Ontology (GO) and KEGG databases. Temora only showed a mild response to both the temperature and the duration of the exposure. We found that the expression of 27 transcripts varied significantly with an increase in temperature of 3 °C, of which eight transcripts were differentially expressed after acute exposure only. Gene set enrichment analysis revealed that, overall, T. longicornis was more impacted by a sustained thermal exposure, rather than an immediate (acute) exposure, with two times as many enriched GO terms in the sustained treatment. We also identified several general stress responses independent of exposure time, such as modified protein synthesis, energy mobilisation, cuticle and chaperone proteins. Finally, we highlighted candidate genes of a possible recovery from heat exposure, identifying similar terms as those enriched in the heat treatments, i.e. related to for example energy metabolism, cuticle genes and extracellular matrix. The data presented in this study provides the first transcriptome available for T. longicornis which can be used for future genomic studies.

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The sugar phosphate/phosphate exchanger family SLC37

Cited by 3 publications

References 85 publications

Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment

Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment

Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16

The transcriptome of the marine calanoid copepod Temora longicornis under heat stress and recovery

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