The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study

Liu, Xiaohui; Wan, Xuzhi; Zhang, Lange; Li, Yin; Yang, An‐Gang; Zhuang, Ping; Wu, Yuqi; Zhang, Yu; Jiao, Jingjing

doi:10.1016/j.clnu.2023.03.011

Cited by 9 publications

(13 citation statements)

References 43 publications

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“…Previous studies have consistently reported that individuals with higher sulfur microbial diet scores related to consuming a high intake of processed meats, liquor, low-calorie drinks, beer, sweets, and desserts and a low intake of mixed vegetables and legumes face an elevated risk of early-onset adenomas and colorectal cancer, with the risk being 1.31 and 1.25 times higher, respectively ( 41 , 42 ). Furthermore, recent research has highlighted the influence of sulfur microbial diet scores on obesity risk and its impact on metabolic processes, based on data from the UK Biobank ( 20 ). However, our current study yielded some intriguing findings.…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy can be attributed to the distinctive dietary habits of Koreans, where the average sulfur microbial diet scores were notably lower (approximately −35 for men and − 55 for women) compared to Europeans (approximately −0.5). This variation arises from the fact that Koreans consume considerably fewer processed meats and consume more legumes and vegetables than their European counterparts ( 20 ). Additionally, our study uncovered a noteworthy interaction between sulfur microbial diet scores and PRS to affect serum HDL concentration.…”

Section: Discussionmentioning

confidence: 99%

“…The GI values listed for common Korean foods were used ( 19 ). The 43 gut microbes related to sulfur metabolism were selected, and food groups positively or negatively associated with the gut microbes were identified in a previous study ( 20 ). The food groups with a positive association were processed meats, liquor, and low-calorie drinks, and those with a negative association were beer, fruit juices, legumes, other vegetables, and sweets or desserts.…”

Section: Methodsmentioning

confidence: 99%

“…The food groups with a positive association were processed meats, liquor, and low-calorie drinks, and those with a negative association were beer, fruit juices, legumes, other vegetables, and sweets or desserts. Sulfur microbial diet scores were calculated by summing the multiplying value of the beta coefficient by the amount of each food item ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

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Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism

Hur,

Yang,

Kim

et al. 2023

Front. Nutr.

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IntroductionHypo-high-density lipoprotein cholesterolemia (hypo-HDL-C) contributes to the development of cardiovascular diseases. The hypothesis that the polygenic variants associated with hypo-HDL-C interact with lifestyle factors was examined in 58,701 middle-aged Korean adults who participated in the Korean Genome and Epidemiology Study (KoGES).MethodsParticipants were categorized into the Low-HDL (case; n = 16,980) and Normal-HDL (n = 41,721) groups. The participants in the Low-HDL group were selected using the guideline-based cutoffs for hypo-HDL-C (<40 mg/dL for men and < 50 mg/dL for women) and included those taking medication for dyslipidemia. The genes associated with hypo-HDL-C were determined through a genome-wide association study (GWAS) in a city hospital-based cohort, and the results were validated in the Ansan/Anung study. The genetic variants for the single nucleotide polymorphism (SNP)-SNP interaction were selected using a generalized multifactor dimensionality reduction analysis, and the polygenic risk score (PRS) generated was evaluated for interaction with lifestyle parameters.ResultsThe participants with hypo-HDL-C showed a 1.45 and 1.36-fold higher association with myocardial infarction and stroke, respectively. The High-PRS with four SNPs, namely ZPR1_rs3741297, CETP_rs708272, BUD13_rs180327, and ALDH1A2_rs588136, and that with the 11q23.3 haplotype were positively associated with hypo-HDL-C by about 3 times, which was a 2.4-fold higher association than the PRS of 24 SNP with p < 5×10−8. The risk alleles of CETP_rs708272 and ALDH1A2_rs588136 were linked to increased expression in the heart and decreased in the brain, respectively. The selected SNPs were linked to the reverse cholesterol transport pathway, triglyceride-rich lipoprotein particle remodeling pathway, cholesterol storage, and macrophage-derived foam cell differentiation regulation. The PRS of the 4-SNP model interacted with energy intake and smoking status, while that of the haplotype interacted with a glycemic index of the diet, sulfur microbial diet, and smoking status.DiscussionAdults with a genetic risk for hypo-HDL-C need to modulate their diet and smoking status to reduce their risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism

Hur,

Yang,

Kim

et al. 2023

Front. Nutr.

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“…Another meta-analysis demonstrated that a low-fat diet can significantly reduce weight and improve cardiovascular risk factors after 6 months ( 21 ). A prospective cohort study found a positive association between a sulfur-microbiota diet and the risk of obesity and abdominal obesity, emphasizing the importance of avoiding a sulfur-microbiota diet in preventing obesity at all genetic risk levels ( 22 ). Investigating recent scholarly work, it is evident that feeding mice a high-energy diet with different fat/sugar ratios can induce obesity in mice ( 23 ).…”

Section: Hfd Promotes the Development Of Metabolic Diseasesmentioning

confidence: 99%

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Jia,

Chen,

et al. 2023

Front. Nutr.

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In the past two decades, the rapid increase in the incidence of metabolic diseases, including obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and hyperuricemia, has been attributed to high-fat diets (HFD) and decreased physical activity levels. Although the phenotypes and pathologies of these metabolic diseases vary, patients with these diseases exhibit disease-specific alterations in the composition and function of their gut microbiota. Studies in germ-free mice have shown that both HFD and gut microbiota can promote the development of metabolic diseases, and HFD can disrupt the balance of gut microbiota. Therefore, investigating the interaction between gut microbiota and HFD in the pathogenesis of metabolic diseases is crucial for identifying novel therapeutic strategies for these diseases. This review takes HFD as the starting point, providing a detailed analysis of the pivotal role of HFD in the development of metabolic disorders. It comprehensively elucidates the impact of HFD on the balance of intestinal microbiota, analyzes the mechanisms underlying gut microbiota dysbiosis leading to metabolic disruptions, and explores the associated genetic factors. Finally, the potential of targeting the gut microbiota as a means to address metabolic disturbances induced by HFD is discussed. In summary, this review offers theoretical support and proposes new research avenues for investigating the role of nutrition-related factors in the pathogenesis of metabolic disorders in the organism.

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The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene–diet study from the UK Biobank

Liu,

Huang,

Ruan

et al. 2024

The American Journal of Clinical Nutrition

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The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study

Cited by 9 publications

References 43 publications

Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism

Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene–diet study from the UK Biobank

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