The ¹²⁵I-Hippuran Renogram in Rabbit Kidneys After Graded Warm Ischaemia

Abstract

125I-Hippuran renography was performed after temporary renal arterial clamping in contralateral nephrectomized rabbits. Mean renograms for the experimenttal groups were calculated for 0, 1, 1 1/2, 2, 2 1/2 and 3 h of warm ischaemia. The appearance phase, the 1 min uptake phase and excretion ratio were evaluated. The kidney function was monitored by serum-creatinine. Warm ischaemia of 1, 1 1/2 and 2 h resulted in a late maximum peak and delayed excretion, and for the last group in an accumulation curve. The uptake capacity was normal for these groups. Protracted ischaemia of 2 1/2 and 3 h affected also the appearance and uptake phase resulting in a slower and decreased Hippuran uptake of 50% and 34% respectively. Duration of warm ischaemia and changes in the renogram were well correlated. A normal uptake phase predicts restitution of the kidney function and 100% survival.

Post re-anastomosis demonstration of regain in function in non-visualized upper half of kidney in a dual arterial allogenic renal graft on renal scintigraphy

“…[3] Several reports have suggested that the absence of perfusion or tracer uptake on renal scintigraphy correlates with conditions that confer a grave prognosis for survival of the renal transplant,[4] uptake of OIH is proportional to the renal viability and is well-correlated to the kidney's ability to regain normal function after ischemic damage, as demonstrated in an animal model. [7] Importantly, it takes only a few minutes after initiation of renal scintigraphy to obtain this critical information, allowing a prompt decision regarding further patient management. [8] Recent evidence indicates that transplant function in those patients can be saved by prompt restoration of blood flow.…”

Συγκριτική Μελέτη Των Επιδράσεων Της Παρατεταμένης Θερμής Και Ψυχρής Ισχαιμίας Στην Νεφρική Λειτουργία Και Στην Κυτταρική Δομή Κατά Τη Διάρκεια Μερικής Νεφρεκτομής

“…Άλλοι συγγραφείς αναφέρουν ότι σε κονίκλους με μονήρη νεφρό, ο οποίος όμως δεν έχει υποστεί μερική νεφρεκτομή, βιοχημικές διαταραχές ξεκινούν να εμφανίζονται μετά από 120 λεπτά θερμής ισχαιμίας (Dahlager et al, 1980). Είναι όμως γνωστό ότι η αφαίρεση νεφρικού παρεγχύματος, πέρα από στρεσσογόνος επέμβαση, επιβαρύνει αισθητά και την συνολική διηθητική ικανότητα του νεφρού .…”