The Superior Colliculus/Lateral Posterior Thalamic Nuclei in Mice Rapidly Transmit Fear Visual Information Through the Theta Frequency Band

Liu, Denghui; Li, Shouhao; Ren, Liqing; Li, Xiaoyuan; Wang, Zhenlong

doi:10.1016/j.neuroscience.2022.06.021

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…Relative to their location, the reduction in f is was most prominent in posterior subregions, particularly the lateral posterior subregions, which act in concert with the pulvinar subregions as key components of the visual pathway. 36 The lower f is observed in subregions located close to the ventricles supports the “ependymal‐in” gradient concept of thalamic damage in MS, 37 analogous to the “pial‐in” cortical gradient demonstrated for cortical damage. 18 , 19 , 38 , 39 Subependymal neuroaxonal loss has been associated with the presence of subependymal perivascular B‐cell infiltrates and soluble inflammatory factors in the cerebrospinal fluid, damaging thalamic tissue directly or indirectly by microglia activation.…”

Section: Discussionsupporting

confidence: 55%

“…Interestingly, atrophy‐prone thalamic subregions showed higher f ec and lower f is , reflecting an increased extra‐cellular space and greater cell body loss. Relative to their location, the reduction in f is was most prominent in posterior subregions, particularly the lateral posterior subregions, which act in concert with the pulvinar subregions as key components of the visual pathway 36 . The lower f is observed in subregions located close to the ventricles supports the “ependymal‐in” gradient concept of thalamic damage in MS, 37 analogous to the “pial‐in” cortical gradient demonstrated for cortical damage 18,19,38,39 .…”

Section: Discussionmentioning

confidence: 53%

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Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

Krijnen,

Salim Karam,

Russo

et al. 2024

Ann Clin Transl Neurol

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ObjectiveTo evaluate the intrinsic and extrinsic microstructural factors contributing to atrophy within individual thalamic subregions in multiple sclerosis using in vivo high‐gradient diffusion MRI.MethodsIn this cross‐sectional study, 41 people with multiple sclerosis and 34 age and sex‐matched healthy controls underwent 3T MRI with up to 300 mT/m gradients using a multi‐shell diffusion protocol consisting of eight b‐values and diffusion time of 19 ms. Each thalamus was parcellated into 25 subregions for volume determination and diffusion metric estimation. The soma and neurite density imaging model was applied to obtain estimates of intra‐neurite, intra‐soma, and extra‐cellular signal fractions for each subregion and within structurally connected white matter trajectories and cortex.ResultsMultiple sclerosis‐related volume loss was more pronounced in posterior/medial subregions than anterior/ventral subregions. Intra‐soma signal fraction was lower in multiple sclerosis, reflecting reduced cell body density, while the extra‐cellular signal fraction was higher, reflecting greater extra‐cellular space, both of which were observed more in posterior/medial subregions than anterior/ventral subregions. Lower intra‐neurite signal fraction in connected normal‐appearing white matter and lower intra‐soma signal fraction of structurally connected cortex were associated with reduced subregional thalamic volumes. Intrinsic and extrinsic microstructural measures independently related to subregional volume with heterogeneity across atrophy‐prone thalamic nuclei. Extrinsic microstructural alterations predicted left anteroventral, intrinsic microstructural alterations predicted bilateral medial pulvinar, and both intrinsic and extrinsic factors predicted lateral geniculate and medial mediodorsal volumes.InterpretationOur results might be reflective of the involvement of anterograde and retrograde degeneration from white matter demyelination and cerebrospinal fluid‐mediated damage in subregional thalamic volume loss.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 53%

Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

Krijnen,

Salim Karam,

Russo

et al. 2024

Ann Clin Transl Neurol

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“…Two small trepanations (diameter: 2 mm) were drilled over the cerebellum and the olfactory bulb to place silver ball electrodes on top of the dura used to ground (olfactory bulb) the animal and to provide the reference signals for local field potentials (cerebellum). A 16‐channel (4 × 4) microelectrode array (length: 5 mm, pitch: 200 μm, Hong Kong Plexon Inc.) 30 was inserted through the dura mater into the dPAG nuclei (anterior–posterior: −3.88 mm; medial–lateral: +0.38 mm; dorsal–ventral: −2.3 mm) according to The Mouse Brain in Stereotaxic Coordinates (third edition) at an angle perpendicular to the cortical surface. A slight dimpling of up to 100 μm of the cortex was accepted.…”

Section: Methodsmentioning

confidence: 99%

Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats

Liu

Ren

et al. 2022

Anim Models and Exp Med

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Background: Flight and freezing are two vital defensive behaviors that mice display to avoid natural enemies. When they are exposed to innate threats, visual cues are processed and transmitted by the visual system into the emotional nuclei and finally transmitted to the periaqueductal gray (PAG) to induce defensive behaviors. However, how the dorsal PAG (dPAG) encodes the two defensive behaviors is unclear.Methods: Multi-array electrodes were implanted in the dPAG nuclei of C57BL/6 mice.Two kinds of visual stimuli (looming and sweeping) were used to induce defensive behaviors in mice. Neural signals under different defense behaviors were recorded, and the encoding characteristics of the two behaviors were extracted and analyzed from spike firing and frequency oscillations. Finally, synchronization of neural activity during the defense process was analyzed.

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GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response

Yuan,

Tan,

Cai

et al. 2024

Neurosci. Bull.

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The Superior Colliculus/Lateral Posterior Thalamic Nuclei in Mice Rapidly Transmit Fear Visual Information Through the Theta Frequency Band

Cited by 4 publications

References 54 publications

Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats

GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response

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