2015
DOI: 10.1111/ecc.12385
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The superparamagnetic iron oxide tracer: a valid alternative in sentinel node biopsy for breast cancer treatment

Abstract: The European Union has determined that from 2016 breast cancer patients should be treated in Specialist Breast Units that achieve the minimum standards for the mandatory quality indicators as defined by Eusoma. The existing standard for axillary lymph node staging in breast cancer is sentinel node biopsy (SNB), performed using Technetium-sulphur colloid ( Tc) alone or with blue dye. The major limits of radioisotope consist in the problems linked to radioactivity, in the shortage of tracer and nuclear medicine … Show more

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Cited by 57 publications
(74 citation statements)
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“…The noninferiority of SLNB using a magnetic substance and a magnetic probe has been verified in the French Sentimag, Nordic Sentimag trial, Sentimag Multicenter Trial, and Central‐European Sentimag trial, as well as other studies . In those studies, patients received injections of both SPIO and 99m Tc, with or without blue dye.…”
Section: Discussionmentioning
confidence: 87%
“…The noninferiority of SLNB using a magnetic substance and a magnetic probe has been verified in the French Sentimag, Nordic Sentimag trial, Sentimag Multicenter Trial, and Central‐European Sentimag trial, as well as other studies . In those studies, patients received injections of both SPIO and 99m Tc, with or without blue dye.…”
Section: Discussionmentioning
confidence: 87%
“…Three more feasibility studies were excluded owing to lack of an appropriate sample size calculation. Seven articles matched the inclusion criteria and were available for meta‐analysis.…”
Section: Resultsmentioning
confidence: 99%
“…The sentinel node detection rates per patient range from 94.4 to 98% [8,9,10,11,12,13,14]. A recent meta-analysis [14] including 7 non-randomised studies [8,9,10,11,12,13,14]showed that Sienna+ is non-inferior to standard mapping techniques for sentinel node detection.…”
Section: Superparamagnetic Iron Oxidementioning
confidence: 99%
“…A recent meta-analysis [14] including 7 non-randomised studies [8,9,10,11,12,13,14]showed that Sienna+ is non-inferior to standard mapping techniques for sentinel node detection. There was no difference in detection rate per patient (fixed odds ratio (OR) 1.10; 95% confidence interval (CI) 0.67-1.79; p = 0.71) between Sienna+ and the standard tracer technique.…”
Section: Superparamagnetic Iron Oxidementioning
confidence: 99%