The FDA Green Book is a list of all drug products that have been
approved by the FDA for use in veterinary medicine. The Green Book,
as published, lacks structural information corresponding to approved
drugs. To address this gap, we have compiled the structural data for
all FDA Green Book drugs approved through the end of 2019. Herein
we discuss the relevance of this data set to human drugs in the context
of structural classes and physicochemical properties. Analysis reveals
that physicochemical properties are highly optimized and consistent
with a high probability of favorable drug metabolism and pharmacokinetic
properties, including good oral bioavailability for most compounds.
We provide a detailed analysis of this data set organized on the basis
of structure and function. Slightly over half (51%) of vet drugs are
also approved in human medicine. Combination drugs are biologics are
also discussed.