The Supply of Oxygen to the Human Small Intestine in Mechanical Ileus

Thermann, M.; Jostarndt, L.; Eberhard, F.; Richter, H; Sass, W

doi:10.1007/978-3-642-71226-5_11

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…From 1985, Thermann et al . [59] have determined the local pO 2 of the small bowel wall, using a multiwire Pt surface electrode. Local pO 2 values of the serosal site of the small bowel of 12 patients were measured at 61.2 (53.0–71.0) mmHg.…”

Section: What Does Physioxia Mean?mentioning

confidence: 99%

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Carreau

Hafny‐Rahbi

Matejuk

et al. 2011

J Cellular Molecular Medi

1,049

935

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Oxygen supply and diffusion into tissues are necessary for survival. The oxygen partial pressure (pO2), which is a key component of the physiological state of an organ, results from the balance between oxygen delivery and its consumption. In mammals, oxygen is transported by red blood cells circulating in a well-organized vasculature. Oxygen delivery is dependent on the metabolic requirements and functional status of each organ. Consequently, in a physiological condition, organ and tissue are characterized by their own unique ‘tissue normoxia’ or ‘physioxia’ status. Tissue oxygenation is severely disturbed during pathological conditions such as cancer, diabetes, coronary heart disease, stroke, etc., which are associated with decrease in pO2, i.e. ‘hypoxia’. In this review, we present an array of methods currently used for assessing tissue oxygenation. We show that hypoxia is marked during tumour development and has strong consequences for oxygenation and its influence upon chemotherapy efficiency. Then we compare this to physiological pO2 values of human organs. Finally we evaluate consequences of physioxia on cell activity and its molecular modulations. More importantly we emphasize the discrepancy between in vivo and in vitro tissue and cells oxygen status which can have detrimental effects on experimental outcome. It appears that the values corresponding to the physioxia are ranging between 11% and 1% O2 whereas current in vitro experimentations are usually performed in 19.95% O2, an artificial context as far as oxygen balance is concerned. It is important to realize that most of the experiments performed in so-called normoxia might be dangerously misleading.

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Section: What Does Physioxia Mean?mentioning

confidence: 99%

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Carreau

Hafny‐Rahbi

Matejuk

et al. 2011

J Cellular Molecular Medi

1,049

935

View full text Add to dashboard Cite

show abstract

“…Importantly, in some tissues, including the intestinal mucosa, a state of physiologic hypoxia exists even in normal physiological circumstances (10,14). PO 2 levels at the serosal aspect of the small intestine are signifi-cantly lower than those of the pulmonary mucosa (70,85). Therefore, different compartments exist in the physiologic state at widely different O 2 levels, some of which are hypoxic.…”

mentioning

confidence: 99%

Determinants of hypoxia-inducible factor activity in the intestinal mucosa

Fagundes

Taylor

2017

Journal of Applied Physiology

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The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and its juxtaposition with the anoxic environment of the intestinal lumen. This frequently results in a state of hypoxia in the healthy mucosa even in the physiologic state. Furthermore, pathophysiologic hypoxia (which is more severe and extensive) is associated with chronic inflammatory diseases including inflammatory bowel disease (IBD). The hypoxia-inducible factor (HIF), a ubiquitously expressed regulator of cellular adaptation to hypoxia, is central to both the adaptive and the inflammatory responses of cells of the intestinal mucosa in IBD patients. In this review, we discuss the microenvironmental factors which influence the level of HIF activity in healthy and inflamed intestinal mucosae and the consequences that increased HIF activity has for tissue function and disease progression.

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“…When the dual sugar test is applied, this contains one monosaccharide suggested to freely move across the small intestine via the transcellular pathway, such as mannitol or rhamnose, and one disaccharide suggested to be able to cross the intestinal epithelial barrier only via the paracellular pathway, such as the disaccharide lactulose [48,49]. The use of two sugars instead of just one is suggested to correct for potential inter-individual differences such as in intestinal transit and renal clearance [48], although only using disaccharide-to-monosaccharide ratios could also lead to wrong conclusions and underestimation of intestinal permeability [50]. More recently, multisugar assays containing 3-5 different inert sugars have been developed to take into account gastric and/or colon permeability, in addition to small intestinal permeability [51,52], or to test for more different types of intestinal transport [53].…”

Section: Intestinal Permeability In Vivomentioning

confidence: 99%

“…One aspect is oxygen availability, which is much higher in routine culture than it actually is in vivo. The partial oxygen pressure in vivo at the serosal (basolateral) side of the intestinal epithelial cells lies around 60 mmHg [43,50], while this is only half at the luminal (apical) side [43]. Studies with Caco-2 monolayers have shown that with routine culture, the partial oxygen pressure of the basolateral medium was around 110 mmHg, which is almost double as seen in the in vivo situation [51].…”

Section: In Vitro Caco-2 Model To Study Intestinal Permeabilitymentioning

confidence: 99%

Good, Bad, or Risky? : intestinal permeability to protein: human and in vitro studies

JanssenDuijghuijsen

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The Supply of Oxygen to the Human Small Intestine in Mechanical Ileus

Cited by 3 publications

References 4 publications

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Determinants of hypoxia-inducible factor activity in the intestinal mucosa

Good, Bad, or Risky? : intestinal permeability to protein: human and in vitro studies

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