2013
DOI: 10.1016/j.bcp.2013.05.009
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The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent

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Cited by 14 publications
(11 citation statements)
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“…The production of NO by activated macrophages can lead to cytostatic and cytotoxic activities on malignant cells (31). The results of the present study revealed that K5-OS 1 and K5-OS 2 markedly induced macrophage-mediated cytotoxicity against cancer cells.…”
supporting
confidence: 50%
“…The production of NO by activated macrophages can lead to cytostatic and cytotoxic activities on malignant cells (31). The results of the present study revealed that K5-OS 1 and K5-OS 2 markedly induced macrophage-mediated cytotoxicity against cancer cells.…”
supporting
confidence: 50%
“…The human protein THO complex 1 (THOC1) was originally identi ed as a nuclear matrix component that binds to the tumor suppressor retinoblastoma (RB) protein [40,41]. Recent research found that high levels of THOC1 were associated with tumor size and aggressiveness in breast and lung cancer cells, and that down-regulation of THOC1 was essential for the NO-mediated cytotoxicity induced by CCL-34 in cancer cells [40].…”
Section: Discussionmentioning
confidence: 99%
“…The human protein THO complex 1 (THOC1) was originally identified as a nuclear matrix component that binds to the tumor suppressor retinoblastoma (RB) protein [36,37]. Recent research found that high levels of THOC1 were associated with tumor size and aggressiveness in breast and lung cancer cells, and that down-regulation of THOC1 was essential for the NO-mediated cytotoxicity induced by CCL-34 in cancer cells [36].…”
Section: Discussionmentioning
confidence: 99%