The Suppressive Effects of the Petroleum Ether Fraction from<i>Atractylodes lancea</i>(Thunb.) DC. On a Collagen-Induced Arthritis Model

Liu, Ren Ping; Tao, En-Wei; Yu, Shuwen; Liu, Bo; Dai, Lingman; Yu, Liangyu; Xiong, Yifeng; Fu, Ruigang; Lei, Lang; Lai, Xiaoping

doi:10.1002/ptr.5671

Cited by 23 publications

(11 citation statements)

References 22 publications

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“…Rheumatoid arthritis is a common systemic autoimmune disease, which is characterized as chronic inflammation of joint synovial tissue and subsequent destruction of associate bone, cartilage, and soft tissues (Liu et al ., ). In RA, the balance is skewed toward Th1 and excess of IL‐2, TNF‐alpha, and IL‐12 production, whereas Th2 activity and the production of IL‐4 and IL‐10 are deficient (Moudgil and Choubey, ; Wu et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

Zhang

Wang

et al. 2017

Phytother. Res.

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Rheumatoid arthritis (RA) is a systemic, Th1 cytokine-predominant autoimmune disease result in a chronic and inflammatory disorder. Geniposide (GE), an iridoid glycoside compound that is purified from Gardenia jasminoides Ellis, has antiinflammatory and other immunoregulatory effects, but its exact mechanism of actions on RA is unknown. The aim of this study was to elucidate antiinflammation effects of GE on adjuvant arthritis (AA) rats and its possible immune tolerance mechanisms. Male Sprague-Dawley rats were administered with GE (30, 60, and 120 mg/kg) orally from day 17 to 24 after immunization. Lymphocyte proliferation was assessed by MTT. Levels of interleukin-2 (IL-2), IL-4, and transforming growth factor-β1 were tested by ELISA. The expression of β2-AR, GRK2, and β-arrestin-1 and β-arrestin-2 was detected by western blot. Geniposide was found to relieve the secondary hind paw swelling and arthritis scores, along with attenuating histopathologic changes and decreasing IL-2 and increasing IL-4, transforming growth factor-β1 in mesenteric lymph node (MLN) lymphocytes of AA rats. In addition, GE in vivo increased the expression of β2-AR and decreased the expression of GRK2, β-arrestin-1 and β-arrestin-2, and level of cyclic adenosine monophosphate of MLN lymphocytes in AA rats. From these results, we can infer that GE on immune tolerance effects, β2-AR desensitization, and β2-AR-AC-cyclic adenosine monophosphate transmembrane signal transduction of MLN lymphocytes plays crucial roles in antiinflammatory and immunoregulatory pathogeneses of RA. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 97%

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

Zhang

Wang

et al. 2017

Phytother. Res.

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“…As the component of HSDTT, Atractylodes lancea (Thumb. )DC not only reduce the expression of in ammatory cytokines in serum, but also decreases the expression of beclin-1 protein in synovial tissue of rat [28].Moreover, Radix Angelicae pubescentis and licorice all have a great effect on alliviating in ammtory ,and Radix Angelicae pubescentis has been shown to relieve pain by inhibiting the expression of TNF-α and IL-1β [29,30]. Angelicae Sinensis Radix inhibits apoptosis of chondrocyte via suppressing JNK and p38MAPK pathways [31].…”

Section: Discussionmentioning

confidence: 98%

Network Pharmacology Approach and Experimental Verification of Huashi Dingtong Decoction Against Knee Osteoarthritis

Haiya

Lai-Jun

Zhang

et al. 2020

Preprint

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Background: The aim of this study is to clarify the ingredients and targets of HSDTT against KOA by network pharmacology,and to verify the mechanism of HSDTT in treatment of KOA in vivo.Methods: Ingredient-target network for HSDTT and KOA was created to identify the potential targets, protein-protein interaction network was used to find the key targets of HSDTT in treatment for KOA, GO enrichment and KEGG pathway was conducted to illuminate the pathway related to KOA treat by HSDTT. Rat model of KOA was established by joint injection in papain.The morphology of cartilage were assessed by H&E. ELISA was used to detect the contents of inflammation cytokines in synovial fluid and synovium. The expression of the pathway protein were assessed by PCR.Results: The results of network pharmacology demonstrate that there are 440 ingredients of HSDTT against knee osteoarthritis by 478 targets.The KEGG enrichment analysis showed that PI3K-Akt signaling pathway, MAPK signaling pathway were the key pathways for HSDTT to treat KOA. Morphology of cartilage was improved in the HSDTT group when compared with the model group. Our experiment show that HSDTT can reduced the expressions of p38 and p53 in cartilage, increased the expression of collagenⅡ. The contents of IL-1β and TNF-α in the synovium and COX-2 and PGE-2 in synovial fluid were decreased significantly in the HSDTT group when compared with the model group.Conclusions: Our study indicadites that HSDTT is capable to alleviate inflammation and delay the progression of KOA by p38MAPK signaling pathway.

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“…Although there was only a Chinese study presented that Shu-Jin-Huo-Xie-Tang may reduce the production of lymphocyte IL-2 after co-culture of the herb with lymphocyte. More than 50% of ingredients in Shu- (Peng et al, 2012;Kong et al, 2013;Funk et al, 2016;Hung and Wu, 2016;Liu et al, 2016;Li et al, 2016). In addition, Du-Huo-Ji-Sheng-Tang has been claimed to mediate an anti-inflammatory effects by promoting lymphatic drainage function in TNF-Tg mice (Chen Y. et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

2020

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We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence the adjunctive use of CHP following a diagnosis of RA. A total of 4,148 RA patients were in both the CHP and non-CHP groups after 1:1 matching. Patients in the CHP group had a significantly lower risk of IS compared to patients in the non-CHP group (adjusted hazard ratio [aHR], 0.67; 95% confidence interval [CI], 0.52-0.86). In the CHP group, patients who used CHP for more than 30 days had a lower risk of IS than their counterparts (aHR: 0.61, 95% CI: 0.40-0.91). Gui-Zhi-Shao-Yao-Zhi-Mu-Tang, Shu-Jin-Huo-Xie-Tang, and Du-Huo-Ji-Sheng-Tang might be associated with a lower risk of IS. Finally, the use of CHP in combination with WM was associated with a decreased risk of IS in patients with RA, especially among those who had used CHP for more than 30 days. A further randomized control trial is required to clarify the casual relationship between these results.

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The Suppressive Effects of the Petroleum Ether Fraction fromAtractylodes lancea(Thunb.) DC. On a Collagen-Induced Arthritis Model

Cited by 23 publications

References 22 publications

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

Network Pharmacology Approach and Experimental Verification of Huashi Dingtong Decoction Against Knee Osteoarthritis

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

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