The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity

Halliday, Gary M.; Damian, Diona L.; Rana, Sabita; Byrne, Scott N.

doi:10.1016/j.jdermsci.2011.12.009

Cited by 46 publications

(38 citation statements)

References 50 publications

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“…Studies of ultraviolet (UV) radiation (A and B wavelengths) have demonstrated both systemic immune suppression and a reduction in DTH responses (reviewed in [34], [35]). Most studies of UV radiation identify regulatory T cells as one cause for reduced immune responsiveness (reviewed in [36]).…”

Section: Discussionmentioning

confidence: 99%

Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function

Zhou

Balint

et al. 2014

PLoS ONE

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The skin serves multiple functions that are critical for life. The protection from pathogens is achieved by a complicated interaction between aggressive effectors and controlling functions that limit damage. Inhomogeneous radiation with limited penetration is used in certain types of therapeutics and is experienced with exposure to solar particle events outside the protection of the Earth’s magnetic field. This study explores the effect of ionizing radiation on skin immune function. We demonstrate that radiation, both homogeneous and inhomogeneous, induces inflammation with resultant specific loss of regulatory T cells from the skin. This results in a hyper-responsive state with increased delayed type hypersensitivity in vivo and CD4+ T cell proliferation in vitro. The effects of inhomogeneous radiation to the skin of astronauts or as part of a therapeutic approach could result in an unexpected enhancement in skin immune function. The effects of this need to be considered in the design of radiation therapy protocols and in the development of countermeasures for extended space travel.

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Section: Discussionmentioning

confidence: 99%

Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function

Zhou

Balint

et al. 2014

PLoS ONE

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“…Diet also affects the immune response and the development of inflammation (Mora et al, 2008;Veldhoen and Brucklacher-Waldert, 2012). Finally, additional factors such as environmental pollutants and ultraviolet light have significant effects on experimental models of autoimmunity and have been linked to human inflammatory disorders (Rook, 2011;Halliday et al, 2012). Although the environment clearly plays a role in the control of immune function, the identity of most of the chemical compounds or perturbations mediating the effects of the environment on the immune response is unknown, making it difficult to identify the molecular mechanisms by which these factors affect immunity.…”

Section: Introductionmentioning

confidence: 99%

Aryl Hydrocarbon Receptor Control of Adaptive Immunity

Quintana

Sherr²

2013

Pharmacol Rev

277

253

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“…It directly receives UV radiation, and it can also be exposed to many environmental toxics. The long term consequences may include photoageing, immunosupression or even malignant processes (Halliday et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Erythrocytes and cell line-based assays to evaluate the cytoprotective activity of antioxidant components obtained from natural sources

Botta

Martı́nez

Mitjans

et al. 2014

Toxicology in Vitro

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Oxidative stress can damage cellular components including DNA, proteins or lipids, and may cause several skin diseases. To protect from this damage and addressing consumer's appeal to natural products, antioxidants obtained from algal and vegetal extracts are being proposed as antioxidants to be incorporated into formulations. Thus, the development of reliable, quick and economic in vitro methods to study the cytoactivity of these products is a meaningful requirement.A combination of erythrocyte and cell line-based assays was performed on two extracts from Sargassum muticum, one from Ulva lactuca, and one from Castanea sativa. Antioxidant properties were assessed in erythrocytes by the TBARS and AAPH assays, and cytotoxicity and antioxidant cytoprotection were assessed in HaCaT and 3T3 cells by the MTT assay. The extracts showed no antioxidant activity on the TBARS assay, whereas their antioxidant capacity in the AAPH assay was demonstrated. On the cytotoxicity assays, extracts showed low toxicity, with IC50 values higher than 200 µg/mL. C. sativa extract showed the most favourable antioxidant properties on the antioxidant cytoprotection assays; while S. muticum and U. lactuca extracts showed a low antioxidant activity. This battery of methods was useful to characterize the biological antioxidant properties of these natural extracts.

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The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity

Cited by 46 publications

References 50 publications

Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function

Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function

Aryl Hydrocarbon Receptor Control of Adaptive Immunity

Erythrocytes and cell line-based assays to evaluate the cytoprotective activity of antioxidant components obtained from natural sources

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