Nano- And Microscale Drug Delivery Systems 2017
DOI: 10.1016/b978-0-323-52727-9.00018-2
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The Supramolecular Complex of Sertraline With Cyclodextrins: Physicochemical and Pharmacological Properties

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Cited by 5 publications
(12 citation statements)
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“…It is worth to mention, that only for RMβCD and SRT molecules the enthalpic effects of binding have been dominated by the entropic effects (|ΔH| < |TΔS|) occurring during the drug-cyclodextrin complex formation (Figure 3). Binding free Gibbs energy (ΔG), enthalpy (ΔH), and entropy factor (TΔS) of inclusion complex formation between SRT and: βCD [41], DMβCD [41], HPβCD [42], RMβCD (this work).…”
Section: Isothermal Titration Calorimetry (Itc)mentioning
confidence: 99%
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“…It is worth to mention, that only for RMβCD and SRT molecules the enthalpic effects of binding have been dominated by the entropic effects (|ΔH| < |TΔS|) occurring during the drug-cyclodextrin complex formation (Figure 3). Binding free Gibbs energy (ΔG), enthalpy (ΔH), and entropy factor (TΔS) of inclusion complex formation between SRT and: βCD [41], DMβCD [41], HPβCD [42], RMβCD (this work).…”
Section: Isothermal Titration Calorimetry (Itc)mentioning
confidence: 99%
“…Moreover, the absolute value of Gibbs free energy of binding (Table 1) for SRT:RMβCD system turned out to be the smallest one. In addition, the complexation processes for all interactions of SRT with chosen β-cyclodextrins are spontaneous-the values Binding free Gibbs energy (∆G), enthalpy (∆H), and entropy factor (T∆S) of inclusion complex formation between SRT and: βCD [41], DMβCD [41], HPβCD [42], RMβCD (this work).…”
Section: Isothermal Titration Calorimetry (Itc)mentioning
confidence: 99%
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“…Циклодекстрины представляют семейство природных циклических олигосахаридов, образованных несколькими глюкопиранозными группами, формирующими кольцо. Они широко используются для конструирования носителей с целью направленной доставки лекарственных средств [37]. Недавно оценены стехиометрия (1:1) и кажущаяся константа ассоциации HP-β-CD (и ряда других циклодекстринов) и рутина, Ks = 390,6 M -1 .…”
Section: результаты протекторный эффект кверцетина и комплекса кверцunclassified