The surface chemistry of metal–organic frameworks and their applications

Abstract

Recent highlights in the surface modification of metal–organic frameworks, from new functionalization protocols to visualisation and application, are discussed.

Metal‐Organic Frameworks and Metal‐Organic Cages – A Perspective

“…[83] Attempts have been made to stabilise MOFs by surface coating and there are undoubtedly opportunities to further develop this aspect of the field. [84] Considerable effort has been made to address the question of MOF stability and some MOFs have been developed which demonstrate excellent stability under a variety of conditions. [85] A notable family of MOFs that exhibit excellent stability are those based on Zr-carboxylates.…”

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

“…18 An increasing number of functionalized MOFs have been synthesized and reported, to realize multifunctional drug delivery. 19 Considerable efforts have also been made to improve the drug delivery capacity of MOFs. 20 Many strategies have now been developed for efficient delivery of drugs, including surface adsorption, pore encapsulation, covalent binding and functional molecules as building blocks.…”

Chemical Stability of Metal‐organic Frameworks for Applications in Drug Delivery

“…Coating the nanoparticle surface by polymers has been proposed as an efficient method to improve the chemical stability of MOFs [60,61] . There are many examples of drug nanocarriers, which have been coated by polyethylene glycol (PEG) to improve their stability (both chemical and colloidal) [62] .…”