The research is set to examine students’ perspectives on using YouTube for English language learning and its impact on their motivation and autonomy in education. A mixed-methods approach was employed, which surveyed 333 English-major students at Van Lang University using a 24-item multiple-choice questionnaire based on the Technology Acceptance Model (TAM). The questionnaire was based on the TAM model, which includes three factors: Perceived Usefulness, Perceived Ease of Use, and Intention of Use. Additionally, semi-structured interviews were conducted with ten students to delve deeper into their individual experiences and perspectives, focusing on the themes of skill development, motivation, and autonomy. Data revealed that students generally find YouTube an effective tool to motivate them to learn English and give them control over their learning. Also, apart from listening, students are found to have their speaking skills enhanced to some extent. This research recommends that English teachers adapt and adjust the use of YouTube for both in-class assignments and homework. Therefore, teachers may encourage their students' motivation and autonomy, eventually resulting in more effective and enjoyable language learning.