Abstract. Nowadays the phenomenon of Global Warming is unequivocal, as confirmed by the latest reports of the IPCC and studies of the climate-change impacts on ecosystems, global economy, and populations. Among these analyses the effect of climate change on groundwater is a very relevant task especially for regions whose economic and social development depends chiefly on groundwater availability, as for the southern Italy. In such a territorial framework, this research was focused on analyzing: i) comparison of precipitation and air temperature obtained by Regional Climate Models (RCMs) and meteorological time series recorded in a part (1950–1996) of the “historical experiment” period (1950–2005); ii) effects of climate change on scenarios of air temperature (T) and precipitation (P) and, consequently, on scenarios of actual evapotranspiration (ETR) and effective precipitation Pe (P – ETR). The latter was considered as a proxy of groundwater recharge of the principal aquifer systems of the region, represented chiefly by the karst aquifers. To achieve a detailed hydro-climatological characterization, an Ensemble of 15 RCMs (E15) derived from the European Coordinated Regional Downscaling Experiment (EURO-CORDEX), at a spatial resolution of 0.11° (~12 km), was analyzed. Specifically, two IPCC Representative Concentration Pathways of greenhouse gases (RCP4.5 and RCP8.5) were considered. The E15 was calibrated in the validation period (1950–1996) by a statistical comparison with data observed by the regional meteorological network managed by the former National Hydrological Service (SIMN), Department of Naples, which was active in the period 1921–1999. As a principal result, the E15 was found with a statistical structure very similar to those of observed annual precipitation (OBSP) and mean annual air temperature (OBST), characterized by a very similar frequency distribution. Accordingly, an inferential statistical approach was performed for calibrating E15 precipitation (E15P) and air temperature (E15T) based on the compensation of the difference with OBSP (+7 %) and OBST (-16 %). The E15 projects a reduction in precipitation and an increase in air temperature under both RCPs, with a divergence point between the two scenarios occurring by about 2040. As a principal result, Pe shows declining trends for both RCP scenarios, reaching a decrease of the 11-yrs moving average down to -20 %, for RCP4.5, and -50 %, for RCP8.5, even if characterized by relevant inter-annual fluctuations.