The Survival Benefits of AIDS Treatment in the United States

Walensky, Rochelle P.; Paltiel, A. David; Losina, Elena; Mercincavage, Lauren M.; Schackman, Bruce R.; Sax, Paul E.; Weinstein, Milton C.; Freedberg, Kenneth A.

doi:10.1086/505147

Cited by 518 publications

(366 citation statements)

References 46 publications

(81 reference statements)

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“…Valcour and Shiramizu [18] have in their work indicated that an increased level of ROS may also increase blood-brain barrier permeability and contribute to HIV-associated dementia. Access to potent antiretroviral therapy (ART) decreases morbidity and mortality due to HIV infection and AIDS [19] and has made HIV infection a manageable chronic illness. Unfortunately, many patients who are prescribed chronic ART experience drug toxicities that include metabolic, hepatic, neurological and cardiovascular complications [20].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Awodele

Olayemi

Nwite

et al. 2011

J Infect Dev Ctries

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Introduction: Among opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS), Mycobacterium tuberculosis is distinguished by its relative virulence and potential for person-to-person transmission. Oxidative stress is associated with TB infection with a high level in patients with HIV-TB co-infection. However, the comparative level of oxidative stress in HIV patients on highly active antiretroviral therapy (HAART) and naïve (untreated) HIV patients is not clear. Methodology: This study is aimed to determine the level of oxidative stress and haematological parameters in HIV patients (naïve), HIV patients undergoing HAART, and HIV-TB co-infected patients. In total, 100 consenting subjects were recruited from the AIDS Prevention Iniative in Nigeria (APIN) Clinic. For controls, normal male healthy volunteers were recruited from the blood donor clinic and females from the APIN clinic staff members, both of the Lagos University Teaching Hospital. Measurements of antioxidant enzyme activity and lipid peroxidation were performed according to standard procedures. Haematological parameters were determined using a fully automated hematology analyzer. Results: Red blood cells significantly decreased (P≤0.001) in all patients when compared with control subjects. The lipid peroxidation (MDA) was significantly high (P≤0.05) in naive patients when compared to HIV patients on HAART. The decrease in the levels of GSH in both naive and HIV-TB co-infected patients (P≤0.001) and HIV patients on HAART (P<0.05) were significant when compared to control patients. Conclusion: There is lower antioxidant level and higher MDA in naive and HIV-TB co-infected patients as compared to HIV patients on HAART and the seronegative patients.

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Section: Introductionmentioning

confidence: 99%

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Awodele

Olayemi

Nwite

et al. 2011

J Infect Dev Ctries

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“…Esto se debería a que la mayor prescripción de fármacos aumenta la complejidad de la posología, aumentando a la vez la posibilidad de interacciones farmacológicas. De esta manera se hace necesario enfatizar la monitorización de los parámetros clínicos, especialmente, en pacientes con más de seis fármacos concomitantes (polifarmacia) de forma de detectar y tratar oportunamente los PRMs que se generen aumentando la efi cacia, seguridad y adherencia del TARV 22,23 .…”

Section: Discussionunclassified

Seguimiento fármaco-terapéutico en pacientes ambulatorios con tratamiento anti-retroviral

Moya¹,

Bernal²,

Rojas³

et al. 2012

Rev. chil. infectol.

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“…The use of antiretroviral therapy (ART) has significantly reduced the mortality and morbidity caused by human immunodeficiency virus type-1 (HIV-1) [1]. ART aims at suppressing HIV-1 replication and enhancing immune reconstitution assessed by increased CD4 + T cell counts [2].…”

Section: Introductionmentioning

confidence: 99%

Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon

Mokhbat

Melhem

El‐Khatib

et al. 2014

J Infect Dev Ctries

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Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. HIV-1 drug resistance (HIVDR) among ART-naive patients has been documented to compromise the success of initial therapy. This study was conducted to determine the prevalence of HIVDR mutations among newly diagnosed drug-naive HIV-infected individuals in Lebanon. Methodology: Plasma samples from 37 newly diagnosed participants at various stages of HIV-1 infection were used to determine HIV-1 RNA viral load, isolate viral RNA, and amplify DNA by RT-PCR. Purified PCR products were used to perform genotypic resistance tests. Results: The prevalence of resistance mutations to nucleoside reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRT), and protease inhibitors (PI) were 5.4%, 10.8%, and 8%, respectively. The major mutations detected in the study participants conferred resistance to NRTIs and NNRTIs recommended for HIV-1 treatment. No significant relationship between HIV-1 viral load of participants and the mode of HIV-1 transmission or between the occurrence of HIVDR and the mode of transmission was found. Conclusions: To our knowledge, this is the first study on HIVDR mutations among newly diagnosed HIV-infected persons in Lebanon. The overall prevalence of HIVDR mutations detected in our study was 16%. Our results are important for evaluating the utility of the standard first-line regimens in use, determining the feasibility of HIVDR testing before the initiation of ART, as well as minimizing the emergence and transmission of HIVDR.

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The Survival Benefits of AIDS Treatment in the United States

Abstract: At least 3.0 million years of life have been saved in the United States as a direct result of care of patients with AIDS, highlighting the significant advances made in HIV disease treatment.

Cited by 518 publications

References 46 publications

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Seguimiento fármaco-terapéutico en pacientes ambulatorios con tratamiento anti-retroviral

Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon

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