The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study)

Rhodes, Andrew; Phillips, Gary; Beale, Richard; Cecconi, Maurizio; Chiche, Jean‐Daniel; Backer, Daniel De; Divatia, Jigeeshu Vasishtha; Du, Bin; Evans, Laura; Ferrer, Ricard; Girardis, Massimo; Koulenti, Despoina; Machado, Flávia Ribeiro; Simpson, Steven Q.; Tan, Cheng Cheng; Wittebole, Xavier; Levy, Mitchell M.

doi:10.1007/s00134-015-3906-y

Cited by 349 publications

(264 citation statements)

References 31 publications

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“…This benefit has also been shown across a wide geographic spectrum. A study of 1794 patients from 62 countries with severe sepsis (now termed "sepsis" after the Sepsis-3 definition [1] or septic shock demonstrated a 36-40% reduction of the odds of dying in the hospital with compliance with either the 3-or 6-h SSC bundles [48]. This recommendation met the prespecified criteria for a BPS.…”

Section: We Recommend That Hospitals and Hospital Systems Have A Perfmentioning

confidence: 96%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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Objective: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". Design:A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. Methods:The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.

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Section: We Recommend That Hospitals and Hospital Systems Have A Perfmentioning

confidence: 96%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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“…A 7.5-year study conducted in 218 centers in USA, South America, and Europe demonstrated that increased compliance with sepsis performance bundles was associated with a reduction in the mortality rate (18). Another investigation conducted in 62 countries also showed that patients with severe sepsis whose care included compliance with all the metrics of the 3 h bundle, and 6 h bundle had 40% and 36% reduction in hospital mortality, respectively (19). A multicenter observational study conducted from September 2007 to October 2008 in 11 ICUs of Chinese teaching hospitals showed that the overall compliance during 6 h resuscitation and 24 h management bundles were 5.5% and 17.4%, respectively (20).…”

Section: Mortality Of Sepsismentioning

confidence: 99%

Current epidemiology of sepsis in mainland China

Liao

et al. 2016

Ann. Transl. Med.

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The disease burden of sepsis is a global issue. Most of the large-scale epidemiological investigations on sepsis have been carried out in developed countries. The population of 1.3 billion in mainland China accounts for approximately 1/5 th of the whole world population. Thus, the knowledge of the incidence and mortality of sepsis in mainland China is vital before employing measures for its improvement. However, most of the epidemiological data of sepsis in mainland China was obtained from ICU settings, and thus lacks the population-based incidence and mortality of sepsis. In the present review, we summarized the limited literature encompassing the incidence, mortality, long-term outcome, and pathogens of sepsis in mainland China. Therefore, it might provide some valuable information regarding the sepsis disease burden and current issues in the management of sepsis in mainland China.

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“…Greater attention should be given to infected and septic patients without organ dysfunction who may benefit from prompt diagnosis and treatment. It is the early application of the Surviving Sepsis Campaign Bundles of Care that has improved outcomes [15].…”

Section: The Uglymentioning

confidence: 99%

The new sepsis consensus definitions: the good, the bad and the ugly

2016

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The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study)

Abstract: Compliance with all of the evidence-based bundle metrics was not high. Patients whose care included compliance with all of these metrics had a 40% reduction in the odds of dying in hospital with the 3-h bundle and 36% for the 6-h bundle.

Cited by 349 publications

References 31 publications

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Current epidemiology of sepsis in mainland China

The new sepsis consensus definitions: the good, the bad and the ugly

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