The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Abstract

Background The serine protease inhibitor-1 (SERPINE1) rs1799889 single nucleotide polymorphism (SNP) has been constantly associated with diabetes mellitus (DM) and its vascular complications. The aim of this meta-analysis was to evaluate this association with combined evidences. Methods The systematic search was performed for studies published up to March 2021 which assess the associations between SERPINE1 rs1799889 SNP and the risks of DM, diabetic retinopathy (DR), diabetic cardiovascular disease (CVD) and diabetic nephropathy (DN). Only case-control studies were identified, and the linkage between SERPINE1 rs1799889 polymorphism and diabetic vascular risks were evaluated using genetic models. Results 51 comparisons were enrolled. The results revealed a significant association with diabetes risk in overall population (allelic: OR = 1.34, 95 % CI = 1.14–1.57, homozygous: OR = 1.66, 95 % CI = 1.23–2.14, heterozygous: OR = 1.35, 95 % CI = 1.08–1.69, dominant: OR = 1.49, 95 % CI = 1.18–1.88, recessive: OR = 1.30, 95 % CI = 1.06–1.59) as well as in Asian descents (allelic: OR = 1.45, 95 % CI = 1.16–1.82, homozygous: OR = 1.88, 95 % CI = 1.29–2.75, heterozygous: OR = 1.47, 95 % CI = 1.08-2.00, dominant: OR = 1.64, 95 % CI = 1.21–2.24, recessive: OR = 1.46, 95 % CI = 1.09–1.96). A significant association was observed with DR risk (homozygous: OR = 1.25, 95 % CI = 1.01–1.56, recessive: OR = 1.20, 95 % CI = 1.01–1.43) for overall population, as for the European subgroup (homozygous: OR = 1.32, 95 % CI = 1.02–1.72, recessive: OR = 1.38, 95 % CI = 1.11–1.71). A significant association were shown with DN risk for overall population (allelic: OR = 1.48, 95 % CI = 1.15–1.90, homozygous: OR = 1.92, 95 % CI = 1.26–2.95, dominant: OR = 1.41, 95 % CI = 1.01–1.97, recessive: OR = 1.78, 95 % CI = 1.27–2.51) and for Asian subgroup (allelic: OR = 1.70, 95 % CI = 1.17–2.47, homozygous: OR = 2.46, 95 % CI = 1.30–4.66, recessive: OR = 2.24, 95 % CI = 1.40–3.59) after ethnicity stratification. No obvious association was implied with overall diabetic CVD risk in any genetic models, or after ethnicity stratification. Conclusions SERPINE1 rs1799889 4G polymorphism may outstand for serving as a genetic synergistic factor in overall DM and DN populations, positively for individuals with Asian descent. The association of SERPINE1 rs1799889 SNP and DR or diabetic CVD risks was not revealed.

Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

“…Taking into account the discrepancy in findings derived from different study, it could be suggested that genetic variability in SERPINE1 is influenced by the ethnicity and/or type of diabetes, as many studies conducted in Asians with T2DM detected significant association between genetic variants of SERPINE1 and DN, whereas studies performed in Caucasians with T1DM did not detect any significant association between SERPINE1 and DN. Our suggestion is in agreement with the conclusion of a recent meta-analysis of SERPINE1 rs1799889 variant, in which Chen et al (2021) concluded that 4G polymorphism could constitute a genetic synergistic factor in overall DM and DN populations, positively for individuals with Asian descent [ 49 ]. It is noteworthy to be mentioned that the association of rs1799889 variant was not revealed significant in diabetic retinopathy and cardiovascular risks [ 49 ].…”

“…Our suggestion is in agreement with the conclusion of a recent meta-analysis of SERPINE1 rs1799889 variant, in which Chen et al (2021) concluded that 4G polymorphism could constitute a genetic synergistic factor in overall DM and DN populations, positively for individuals with Asian descent [ 49 ]. It is noteworthy to be mentioned that the association of rs1799889 variant was not revealed significant in diabetic retinopathy and cardiovascular risks [ 49 ].…”

Association of polymorphic variants of hemostatic system genes with the course of COVID-19

“…* -the significance of the differences was calculated relative to the corresponding indicators of 1 st group. показателям европейской популяции [12]. Продуктом гена SERPINE1 является белок РАI-1 (plasminogen activator inhibitor-1), основная функция которого ингибировать активатор плазминогена как клеточного, так и урокиназного типа [13].…”